基于第三代头孢菌素药动学相关研究的可视化分析

目的 梳理Web of Science数据库中关于第三代头孢菌素药动学(Pharmacokinetics, PK)研究，通过文献计量学和可视化分析方法，评价该领域的研究方向、研究热点以及发展趋势，为今后研究提供经验和借鉴。方法 使用Web of Science数据库进行检索，检索式为“Theme=("Third-Generation Cephalosporin"OR Cefoperazone) OR Ceftazidime) OR Cefixime) OR Cefodizime) OR Ceftriaxone) OR Cefotaxime) AND (pharmacokinetics OR PK OR"Population pharmacokinetics")”，检索时间为2009-2020年。利用VOS-viewer软件进行合著分析(作者、机构、国家)、共现分析和共引分析；通过GraphPadPrism8软件进行第三代头孢菌素药动学研究的趋势分析。结果 对纳入的818篇文献进行可视化分析，结果显示发文量呈现逐年上涨趋势，其中发文量最多的国家是美国(288篇，35.21%)，最多的期刊...

Bibliometric and visualized analysis of pharmacokinetics of the third-generation cephalosporins

Abstract Objective The research on pharmacokinetics of the third-generation cephalosporis in Web ofScience database was reviewed, and the research direction, hot topics and general trends in this field were evaluatedthrough bibliometric and visualized analysis methods, so as to provide experience and reference for future research.Methods Publications related to the studies of pharmacokinetics of the third-generation cephalosporins from2009 to 2020 were retrieved from the Web of Science database. The search format was "Theme=("Third-GenerationCephalosporin" OR Cefoperazone) OR Ceftazidime) OR Cefixime) OR Cefodizime) OR Ceftriaxone) OR Cefotaxime)AND (pharmacokinetics OR PK OR "Population pharmacokinetics")". For visualized study, co-authorship analysis,co-citation analysis, co-occurrence analysis, and the analysis of publication trends in pharmacokinetics of the thirdgenerationcephalosporins research were conducted by VOS-viewer and GraphPadPrism 8 software. Results Thevisualization analysis of 818 included literatures shows that the number of published papers is increasing year by year.The country with the most published papers is the United States (288 articles, 35.208%), the journal with the mostpublished papers is Antimicrobial Agents and Chemotherapy (113 articles, 13.81%), and the institution with the mostpublished papers is University of Queensland (45 articles, 5.501%), and the most frequent author is Roberts, JA (43articles, 5.257%). Through the clustering analysis for 160 keywords with occurrence frequency of not less than 10times, the pharmacokinetic research direction of the three generations of cephalosporins are mainly concentrated inthe patient population and dosing method, "pharmacokinetic experiment method", "resistance" and "Drug therapy",and the research focuses on the new beta lactamase inhibitor. Based on the analysis of 49 citations with high citationfrequency, the most cited topic in recent years is the post-marketing evaluation of ceftazidime-avibatan. ConclusionIn recent years, the research on pharmacokinetics of third-generation cephalosporins has been heating up, and theresearch on pharmacokinetics and pharmacodynamics of compound preparations composed of novel β-lactamaseinhibitors and third-generation cephalosporins will be the research direction and hot spot in the future.