2001-2019年深圳市南山区结直肠癌发病及趋势分析

目的:了解深圳市南山区2001-2019年结直肠癌发病的流行特征及变化趋势，为针对性开展结直肠癌防治提供参考依据。方法:根据深圳市慢性病防治管理系统登记的2001-2019年南山区常住户籍人口诊断为结直肠癌的所有病例数据，计算结直肠癌粗发病率、中标率、世标率、年龄别发病率。采用Joinpoint回归分析结直肠癌发病的时间趋势，计算年度发病变化百分比（annual percent change，APC）。结果:南山区2001-2019年共报告结直肠癌新发病例1 732例，粗发病率16.96/10万，中标率23.16/10万，世标率23.79/10万。男女发病比为1.46∶1，不同性别间的年龄别发病率均呈上升趋势。结直肠癌发病率随着年龄增长而升高，0~69岁的人群发病率上升趋势尤为显著， 85岁及以上的人群发病率则达到高峰。世标率从2001年的13.30/10万上升至2019年的35.20/10万，Joinpoint结果显示，2001-2019年结直肠癌的世标率APC为3.91%（P＜0.01）。结论:南山区结直肠癌发病形势严峻，为降低其发病率，结直肠癌筛查及早诊早治工作应要积极落实推进。

Incidence and trends of colorectal cancer in Nanshan district,Shenzhen City,from 2001 to 2019

Objective:To analyze the incidence and trends of colorectal cancer in Nanshan district,Shenzhen city,from 2001 to 2019,and to provide effective reference for prevention and treatment strategies for colorectal cancer.Methods:The colorectal cancer incidence data of Nanshan district from 2001 to 2019 registered by the Chronic Disease Prevention and Management System of Shenzhen was used to calculate the crude morbidity,age-specific incidence rate and age-standardized morbidity(Chinese age-standardized morbidity(ASR China),Global age-standardized morbidity(ASR world).The temporal trends of colorectal cancer were analyzed by Joinpoint 4.8.0.1 software,caculate the annual percent change(APC).Results:There were 1 732 new cases of colorectal cancer were reported in Nanshan district from 2001 to 2019.From 2001 to 2019,the incidence of colorectal cancer was 16.96/105,the Chinese age-standardized morbidity was 23.16/105,and the Global age-standardized morbidity was 23.79/105.The gender ratio of male to female was 1.46∶1 and the age-specific incidence rates of different genders showed an overall upward trend.The incidence of colorectal cancer increased significantly with age,and the incidence of the population aged 85 and above reached a peak.The incidence of colorectal cancer increased from 13.30/105 in 2001 to 35.20/105 in 2019(APC=3.91%,t=5.2,P＜0.01).Conclusion:The overall incidence of colorectal cancer in Nanshan district increased.To decrease the incidence rate of colorectal cancer,colorectal cancer screening and early detection and early treatment should be widely promoted.