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| COPB2在肿瘤发生发展中的研究进展 | |
| 引用本文： | 吴 彪,郭显林,张素青. COPB2在肿瘤发生发展中的研究进展[J]. 现代肿瘤医学, 2022, 0(19): 3629-3633. DOI: 10.3969/j.issn.1672-4992.2022.19.039 |
| 作者姓名： | 吴 彪 郭显林 张素青 |
| 作者单位： | 南通大学附属肿瘤医院肝胆胰外科，江苏 南通 226361 |
| 基金项目： | 江苏省南通市卫生科学技术奖励项目（编号:学科09）;江苏省南通市“226高层次人才培养工程”项目（编号:YYRC1713） |
| 摘 要： | 外被体蛋白复合物β’亚基(COPB2)是外被体蛋白复合物(COPI)的组成亚基之一，具有色氨酸-天冬氨酸(WD)重复序列，其与信号转导、细胞周期的调节和细胞凋亡相关。COPB2在人类多种肿瘤中异常表达，且与临床病理特征密切相关，通过多种机制调节细胞增殖、凋亡、侵袭等生物学功能，可作为肿瘤生物标志物和治疗靶点。本文就COPB2在肿瘤发生、发展中的生物学功能、主要的相关机制和潜在临床意义作一综述。 |
| 关 键 词： | COPB2 肿瘤 增殖 凋亡 |
Research progress of COPB2 in tumor development |
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| WU Biao,GUO Xianlin,ZHANG Suqing. Research progress of COPB2 in tumor development[J]. Journal of Modern Oncology, 2022, 0(19): 3629-3633. DOI: 10.3969/j.issn.1672-4992.2022.19.039 | |
| Authors: | WU Biao GUO Xianlin ZHANG Suqing |
| Affiliation: | Hepatopancreatobiliary Surgery Department，Cancer Hospital Affiliated to Nantong University，Jiangsu Nantong 226361，China. |
| Abstract: | The coatomer protein complex subunit beta 2(COPB2) is one of the component subunits of the coatomer complex I(COPI),and has a tryptophan-aspartic(WD) repeat sequence,which is associated with signal transduction,regulation of the cell cycle and apoptosis.COPB2 is aberrantly expressed in a variety of human tumors and is closely related to clinicopathological features.It regulates cell proliferation,apoptosis,invasion and other biological functions through various mechanisms,and can be used as a tumor biomarker and therapeutic target.This article reviews the biological function,main related mechanism and potential clinical significance of COPB2 in tumorigenesis and development. |
| Keywords: | COPB2 tumour proliferation apoptosis |
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