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Systemic mast cell disease associated with primary ovarian mixed malignant germ cell tumor
Authors:Michael Teitell MD  PhD  Jon M Rowland MD  PhD
Affiliation:Department of Pathology, Childrens Hospital Los Angeles and University of Southern California School of Medicine and the Departments of Pathology and Laboratory Medicine and Molecular Biology Institute, UCLA School of Medicine, Los Angeles, CA, USA
Abstract:
A 12-year-old girl with a mixed malignant germ cell tumor of the ovary, treated by surgery and chemotherapy, developed systemic mast cell disease (SMCD) approximately 3 months after chemotherapy. Hematologic malignancies have previously been noted in patients with mediastinal germ cell tumors but this is the first report of a primary ovarian germ cell neoplasm associated with SMCD.
Keywords:Germ cell tumor   systemic mast cell disease   mastocytosis   ovary
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