p53蛋白在恶性肿瘤组织中的表达及意义

用免疫组织化学Ｓ－Ｐ染色方法检测了３０种不同组织起源的２９４例良、恶性肿瘤中ｐ５３蛋白的表达情况，结果显示：在２３８例恶性肿瘤中，有１３０例阳性，阳性率为５４．６２％。在５６例良性肿瘤中有３例阳性，阳性率为５．３５％。良、恶性肿瘤的阳性率之间有明显的差异性（Ｐ＜０．０１）。结果表明ｐ５３基因的变化在人类恶性肿瘤中常见，ｐ５３基因的变化可能是人类多种肿瘤恶性转化的原因之一。

p53 Protein Aberrant Expression and Its Signficance in Human Malignant Tumors

p53 protein expression was studied immunohistochemically in a series of 238 malignant tumors and 56 benign tumors from 30 histological types p53 protein was identified with monocolonal antibody DO 7 in 54 62%(130/238) of malignant tumors and 5 35%(3/56) of benign tumors, whereas there was a higher positive frequency in epithelia malignant tumors including nasopharyneal carcinoma, adenocarcinoma of colorectum, squamous cell carcinoma of esophagus and lung, bladder carcinoma, adenocarcinoma of ovary,and there were three cases positive among 56 cases of benign tumors Positive frequency was very different between malignant and benign tumors ( P <0 01) It suggested that p53 mutation or aberrant expression was common in malignant tumors and the change of p53 gene played a major role in human malignancies