Association of the CYP39A1 G204E Genetic Variant with Increased Risk of Glaucoma and Blindness in Patients with Exfoliation Syndrome |
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| Affiliation: | 1. Singapore Eye Research Institute and Singapore National Eye Center, Singapore;2. Duke-NUS Medical School, Singapore;3. Ozaki Eye Hospital, Hyuga, Miyazaki, Japan;4. Department of Ophthalmology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan;5. Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan;6. Mizoguchi Eye Hospital, Sasebo, Nagasaki, Japan;7. Department of Ophthalmology, Oita University Faculty of Medicine, Yufu-City, Oita, Japan;8. Sensho-kai Eye Institute, Uji, Kyoto, Japan;9. Inouye Eye Hospital, Tokyo, Japan;10. Hayashi Eye Hospital, Fukuoka, Japan;11. Department of Ophthalmology Kanazawa University Graduate School of Medical Science, Kanazawa, Japan;12. Ideta Heisei Retina Consultants, Kumamoto, Japan;13. Hiroshima University Department of Ophthalmology and Visual Sciences, Hiroshima, Japan;14. Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan;15. Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan;16. Department of Ophthalmology, Faculty of Medical Science, University of Fukui, Fukui, Japan;17. Genome Institute of Singapore, Singapore;18. Yong Loo Lin School of Medicine, National University of Singapore, Singapore;1. NORC at the University of Chicago, Chicago, Illinois;2. Division of Diabetes Translation, Centers for Disease Control and Prevention, Atlanta, Georgia;1. Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands;2. Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania;3. Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania;1. Department of Ophthalmology, St. Michael’s Hospital/Unity Health Toronto, Toronto, Canada;2. Department of Ophthalmology & Vision Sciences, University of Toronto, Toronto, Canada;3. Department of Ophthalmology & Visual Sciences, Dalhousie University, Halifax, Canada;4. Newcastle Eye Centre, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom;5. Hamilton Regional Eye Institute, St. Joseph’s Healthcare, Division of Ophthalmology, Department of Surgery, McMaster University, Hamilton, Canada;6. Translational and Clinical Research Institute, Newcastle University, United Kingdom;7. Kensington Vision and Research Center, Toronto, Canada;1. Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, Tennessee;2. Illinois Eye and Ear Infirmary, University of Illinois College of Medicine at Chicago, Chicago, Illinois;3. Department of Ophthalmology, University of California San Francisco, San Francisco, California;4. Ophthalmic Surgeons and Consultants of Ohio, Columbus, Ohio;5. Gavin Herbert Eye Institute, University of California, Irvine School of Medicine, Irvine, California;6. Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts;7. Ophthalmic Plastic Surgery, Lions Eye Institute, Department of Ophthalmology, Albany Medical Center, Albany (Slingerlands), New York;8. Ruiz Department of Ophthalmology and Visual Sciences, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, Texas;9. Cullen Eye Institute, Baylor College of Medicine, Houston, Texas |
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| Keywords: | Blindness Exfoliation glaucoma Exfoliation syndrome Rare variant Whole exome sequencing AMD" },{" #name" :" keyword" ," $" :{" id" :" kwrd0040" }," $$" :[{" #name" :" text" ," _" :" age-related macular degeneration CI" },{" #name" :" keyword" ," $" :{" id" :" kwrd0050" }," $$" :[{" #name" :" text" ," _" :" confidence interval CDR" },{" #name" :" keyword" ," $" :{" id" :" kwrd0060" }," $$" :[{" #name" :" text" ," _" :" cup-disc ratio dB" },{" #name" :" keyword" ," $" :{" id" :" kwrd0070" }," $$" :[{" #name" :" text" ," _" :" decibels IOP" },{" #name" :" keyword" ," $" :{" id" :" kwrd0080" }," $$" :[{" #name" :" text" ," _" :" intraocular pressure MD" },{" #name" :" keyword" ," $" :{" id" :" kwrd0090" }," $$" :[{" #name" :" text" ," _" :" mean deviation OR" },{" #name" :" keyword" ," $" :{" id" :" kwrd0100" }," $$" :[{" #name" :" text" ," _" :" odds ratio SD" },{" #name" :" keyword" ," $" :{" id" :" kwrd0110" }," $$" :[{" #name" :" text" ," _" :" standard deviation VA" },{" #name" :" keyword" ," $" :{" id" :" kwrd0120" }," $$" :[{" #name" :" text" ," _" :" visual acuity VF" },{" #name" :" keyword" ," $" :{" id" :" kwrd0130" }," $$" :[{" #name" :" text" ," _" :" visual field XFG" },{" #name" :" keyword" ," $" :{" id" :" kwrd0140" }," $$" :[{" #name" :" text" ," _" :" exfoliation glaucoma XFS" },{" #name" :" keyword" ," $" :{" id" :" kwrd0150" }," $$" :[{" #name" :" text" ," _" :" exfoliation syndrome |
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