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Habitual Coffee Consumption Increases Risk of Primary Open-Angle Glaucoma: A Mendelian Randomization Study
Institution:1. Eye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China;2. National Clinical Research Center for Ocular Disease, Wenzhou, Zhejiang, China;3. Opthalmology Department, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China;4. Department of Neurology of Shanxi Cardiovascular Hospital, Taiyuan, Shanxi, China;1. Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, People’s Republic of China;2. Department of Ophthalmology, Queen Mary Hospital, Pok Fu Lam, Hong Kong, People’s Republic of China;3. Hong Kong Eye Hospital, Kowloon City, Hong Kong, People’s Republic of China;1. F.I. Proctor Foundation, University of California, San Francisco, California;2. Department of Ophthalmology, University of California, San Francisco, California;3. Department of Epidemiology and Biostatistics, University of California, San Francisco, California;1. Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, Texas;2. Department of Biostatistics and Bioinformatics, Emory University, Atlanta, Georgia;3. Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts;4. Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina;5. Department of Ophthalmology, Zucker School of Medicine at Hofstra/Northwell Health, Great Neck, New York;6. Department of Ophthalmology, Stanford University School of Medicine, Palo Alto, California;1. Sierra Eye Associates, and the University of Nevada, Reno, School of Medicine, Reno, Nevada;2. Retina Consultants Texas, Retina Consultants of America, Houston, Texas;3. Department of Ophthalmology, Duke University, Durham, North Carolina;4. Blanton Eye Institute, Houston Methodist Hospital, Houston, Texas;5. Novartis Pharmaceuticals Corporation, East Hanover, New Jersey;6. Ophthalmic Consultants of Boston, Boston, Massachusetts
Abstract:
Keywords:Coffee consumption  Mendelian randomization  Primary open-angle glaucoma  CI"}  {"#name":"keyword"  "$":{"id":"kwrd0030"}  "$$":[{"#name":"text"  "_":"confidence interval  GWAS"}  {"#name":"keyword"  "$":{"id":"kwrd0040"}  "$$":[{"#name":"text"  "_":"genome-wide association study  IOP"}  {"#name":"keyword"  "$":{"id":"kwrd0050"}  "$$":[{"#name":"text"  "_":"intraocular pressure  IVW"}  {"#name":"keyword"  "$":{"id":"kwrd0060"}  "$$":[{"#name":"text"  "_":"inverse variance-weighted  MBE"}  {"#name":"keyword"  "$":{"id":"kwrd0070"}  "$$":[{"#name":"text"  "_":"mode-based estimate  MR"}  {"#name":"keyword"  "$":{"id":"kwrd0080"}  "$$":[{"#name":"text"  "_":"Mendelian randomization  OR"}  {"#name":"keyword"  "$":{"id":"kwrd0090"}  "$$":[{"#name":"text"  "_":"odds ratio  POAG"}  {"#name":"keyword"  "$":{"id":"kwrd0100"}  "$$":[{"#name":"text"  "_":"primary open-angle glaucoma  PRESSO"}  {"#name":"keyword"  "$":{"id":"kwrd0110"}  "$$":[{"#name":"text"  "_":"Pleiotropy RESidual Sum and Outlier  RCT"}  {"#name":"keyword"  "$":{"id":"kwrd0120"}  "$$":[{"#name":"text"  "_":"randomized clinical trial  SE"}  {"#name":"keyword"  "$":{"id":"kwd016"}  "$$":[{"#name":"text"  "_":"standard error  SNP"}  {"#name":"keyword"  "$":{"id":"kwrd0130"}  "$$":[{"#name":"text"  "_":"single nucleotide polymorphism
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