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Selenium protects against the likelihood of fetal neural tube defects partly via the arginine metabolic pathway
Institution:1. Center for Reproductive Medicine, Department of Obstetrics and Gynecology, National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital), Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education, Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology (Peking University Third Hospital), Beijing, China;2. Institute of Reproductive and Child Health/National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing, China;3. Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China;4. State Key Joint Laboratory for Environmental Simulation and Pollution Control, College of Environmental Sciences and Engineering and Center for Environment and Health, Peking University, Beijing, China;5. Cancer Center of Shanxi Bethune Hospital, Shanxi Academy of Medical Science, Taiyuan, China;6. Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China;1. Department of Nutrition, Federal University of Piauí, Campus Ministro Petrônio Portella, Teresina, Piauí, 64049-550, Brazil;2. School of Nursing, Department of Nutrition, Federal University of Minas Gerais, 6627 Av. Pres. Antônio Carlos, Belo Horizonte, Minas Gerais, 31270-901, Brazil;1. Department of Nutritional Sciences, King''s College London, London, United Kingdom;2. Department of Nutrition and Dietetics, Guy''s and St Thomas'' NHS Foundation Trust, London, United Kingdom;3. Adult Inherited Metabolic Diseases, Guy''s and St Thomas'' NHS Foundation Trust, London, United Kingdom;4. Centre for Human and Applied Physiological Sciences, King''s College London, London, United Kingdom;5. School of Food and Nutritional Sciences, University College Cork, College Road, Cork, Ireland;1. Department of Food Science and Nutrition, Keimyung University, Daegu, South Korea;2. Department of Food Science and Technology, University of Nebraska-Lincoln, Lincoln, NE, USA;1. Department of Nursing, Shanghai Proton and Heavy Ion Center; Shanghai Key Laboratory of Radiation Oncology (20dz2261000); Shanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy, 4365 Kangxin Road, Shanghai, 201315, China;2. School of Nursing, University of Rochester, New York 14642, United States;3. Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institution, Liaoning, 110042, China;1. Medical University Department, Division of General Internal and Emergency Medicine, Kantonsspital Aarau, Aarau, Switzerland;2. Department of Health Professions, Bern University of Applied Sciences, Bern, Switzerland;3. Faculty of Life Sciences, University of Vienna, Vienna, Austria;4. The New York Academy of Sciences, New York, NY, USA;5. NOVA Medical School, Universidade NOVA de Lisboa, Lisboa, Portugal;6. Internal Medicine, Kantonsspital Münsterlingen, Münsterlingen, Switzerland;7. Internal Medicine and Endocrinology, Kantonsspital St Gallen, St Gallen, Switzerland;8. Internal Medicine, Kantonsspital Luzern, Luzern, Switzerland;9. Internal Medicine, Bürgerspital Solothurn, Solothurn, Switzerland;10. Internal Medicine, Kantonsspital Baselland, Standort Bruderholz, Switzerland;11. Department of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland;12. Institute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland;13. Division of General Internal Medicine, Brigham and Women''s Hospital, Boston, MA, USA;14. Division of Diabetes, Endocrinology, Nutritional Medicine, and Metabolism, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland;15. Nottingham Digestive Diseases Centre and National Institute for Health Research Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and University of Nottingham, Queen''s Medical Centre, Nottingham, UK;p. MRC Versus Arthritis Centre for Musculoskeletal Ageing Research, School of Life Sciences, University of Nottingham, Queen''s Medical Centre, Nottingham, UK;q. Clinical Nutrition and Metabolism, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden;r. Theme Inflammation and Aging, Karolinska University Hospital, Stockholm, Sweden;s. Medical Faculty of the University of Basel, Basel, Switzerland;1. Dept. of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Uppsala, Sweden;2. Dept. of Medical Sciences, Section of Gastroenterology and Hepatology, Uppsala University, Uppsala, Sweden;3. Antaros Medical AB, BioVenture Hub, Mölndal, Sweden;4. MedTech West, Chalmers University of Technology, Gothenburg, Sweden;5. Dept. of Clinical Genetics and Genomics, Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden;6. Dept. of Translational Medicine and Clinical Pharmacology, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany;7. Dept. of Pathology, Aalborg University Hospital, Aalborg, Denmark;8. Dept. of Clinical Medicine, Aalborg University, Aalborg, Denmark;9. Dept. of Surgical Sciences, Radiology, Uppsala University, Uppsala, Sweden
Abstract:
Keywords:Neural tube defects  Selenium  Arginine metabolic pathway  Asymmetric dimethylarginine  Ornithine  Mediating effect
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