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| 肿瘤坏死因子单克隆抗体对急性胆管炎大鼠的器官保护作用 | |
| 引用本文： | 李斌,杨春明,王迎宾. 肿瘤坏死因子单克隆抗体对急性胆管炎大鼠的器官保护作用[J]. 中华普通外科杂志, 1999, 0(1): 59-60 |
| 作者姓名： | 李斌 杨春明 王迎宾 |
| 作者单位： | 大连大学医学院附属医院普外科(李斌)，大连医科大学附属二院(杨春明)，山西大同第五人民医院(王迎宾) |
| 摘 要： | 目的探讨肿瘤坏死因子（ｔｕｍｏｒｎｅｃｒｏｓｉｓｆａｃｔｏｒ，ＴＮＦ）单克隆抗体（ｍｏｎｏｃｌｏｎａｌａｎｔｉｂｏｄｙ，ＭｃＡｂ）对急性胆管炎大鼠多器官损害是否具有保护作用。方法ＳＤ大鼠２４只，随机分成假手术组、急性胆管炎组和ＴＮＦＭｃＡｂ防治组。分别测定血浆ＴＮＦ、血清ＡＬＴ和ＢＵＮ，并行肝、肺、肾病理变化观察。结果ＴＮＦＭｃＡｂ防治组血浆ＴＮＦ明显低于急性胆管炎组（Ｐ＜００１），血清ＡＬＴ、ＢＵＮ亦明显低于急性胆管炎组（Ｐ＜００５），肝、肺、肾病理变化明显减轻。结论ＴＮＦ是导致急性胆管炎多器官损害的重要介质，ＴＮＦＭｃＡｂ对多器官损害具有保护作用 |
| 关 键 词： | 胆管炎 肿瘤坏死因子 抗体.单克隆 |
Protective effect of TNF McAb on vital organs of rats with acute cholangitis |
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| Abstract: | Objective In order to study the protective effect of monoclonal antibody to TNF(TNF McAb) on vital organs of rats in acute cholangitis.Methods Twenty four SD rats were divided at random into sham operation group,acute cholangitis group and treatment group using TNF McAb.The serum levels of TNF,ALT and BUN were ditermined, and the pathological changes of the liver,lung and kidney were observed.Results In the treatment group,the serum levels of TNF decreased significantly than that in acute cholangitis group( P <0 01), and the serum levels of ALT, BUN decreased significantly also ( P <0 05).Conclusions TNF is an important mediator in the development of multiple organs damage in acute cholangitis, and TNF-McAb plays a protective role against multple organ damage. |
| Keywords: | Cholangitis Tumor necrosis factor Antibodies monoclonal |
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