循环免疫复合物与补体测定对SLR临床意义的比较

本文比较54例SLE患者循环免疫复合物(CIC)和补体的临床意义.肾脏受累组的CH₅₀和C₃在病情活动期较缓解期明显降低,其降低程度与病情活动程度平行;而两期的CIC均值都在正常范围内.无肾脏受累组的PEGP在病情活动期较缓解期有明显升高,升高程度与病情活动程度平行;ACA,CH₅₀和C₃则无明显意义.观察结果还提示PEGP异常升高对无肾脏受累者病情加重可能有预测作用.

Comparative evaluation of clinical significance of circulating immune complexes and complement in SLE

In the present study, the clinical significance of circulating immune complexes (CIC)and complement is evaluated in fifty-four patients with SLE. In nephritis group, CH₅₀ and C₃ levels were significaatly lower in active stage compared to those in inactive stage, and the degree of reduction of CH₅₀ and C₃ levels was correlated to the disease activity.The mean valuse of CIC were in normal range in both active and inactive stages. In non-nephritis group, CIC by PEGP method was significantyly higher in active stage compared to those in inactive stage, and was parallel to the degree of disease activity. However, the changes in ACA, CH₅₀ and C₃ failed to show any significant differences between the two stages.The results in this study also suggested that an abnormal increase of CIC level by PEGP method might be used for the prediction of the exacerbation of the disease in non-nephritis group.