双水平气道正压对OSAHS患者预后及血管内皮功能的影响

目的 分析双水平气道正压双水平气道正压通气(bi-level positive airway pressure, BiPAP)对阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea hypopnea syndrome, OSAHS)患者血管内皮功能及预后的影响。方法 将100例OSAHS患者纳入研究，随机分为观察及对照组，各50例。观察组行BiPAP,对照组行常规治疗，比较两组多导睡眠监测(polysomnography, PSG)检查指标(低通气指数、呼吸暂停指数、呼吸暂停及低通气时间、90%以下血氧饱和度次数、90%以下血氧饱和度时间)、心肺功能[脑钠肽(brainnatriureticpeptide, BNP)、右心室Tei指数、左心室Tei指数、一秒用力呼气容积占用力肺活量的百分比(forced expiratory volume in one second/forced vital capacity, FEV1/FVC)、一秒用力呼气容积占预计值的百分比(FEV1占预计值%)]、血管内皮功能[内皮素1(endothelin-1,ET-1)、一氧化氮(...

Effect of bi-level positive airway pressure on prognosis and vascular endothelial function in patients with OSAHS

Objective To analyze the effect of bi-level positive airway pressure(BiPAP) on the prognosis and vascular endothelial function of patients with obstructive sleep apnea hypopnea syndrome(OSAHS).Methods In total, 100 patients with OSAHS were included in the study, and randomly divided into observation group(n=50) and control group(n=50).The observation group was treated with BiPAP, while the control group was given routine treatment.Polysomnography(PSG) indexes(hypoventilation index, apnea index, apnea and hypopnea time, times of oxygen saturation below 90%, time of oxygen saturation below 90%), cardiopulmonary function brain natriuretic peptide(BNP), Tei index of the right ventricle, Tei index of the left ventricle, forced expiratory volume in one second/forced vital capacity(FEV1/FVC), forced expiratory volume in one second as a percentage of expected value(FEV1%pred), vascular endothelial function ［endothelin-1(ET-1), nitric oxide(NO), antithrombinⅢ(AT-Ⅲ)］ and quality of life were compared between two groups.Results The hypoventilation index, apnea index, apnea and hypopnea time, times of blood oxygen saturation below 90% and time indexes of blood oxygen saturation below 90% in the observation group were significantly lower than those in the control group(P＜0.05). After treatment, BNP and Tei index in the observation group were significantly lower than those before treatment and after treatment in the control group. FEV1/FVC and FEV1%pred in the observation group were significantly higher than those before and after treatment in the control group(P＜0.05). After treatment, ET-1 and AT-Ⅲ in the observation group were lower than those before treatment and after treatment in the control group, while NO in the observation group was higher than that before treatment and after treatment in the control group(P＜0.05). The scores of quality of life in the observation group were significantly higher than those in the control group(P＜0.05).Conclusion BiPAP treatment can improve the prognosis and vascular endothelial function of patients with OSAHS, showing definite curative effect.