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KPC and NDM-1 Genes in Related Enterobacteriaceae Strains and Plasmids from Pakistan and the United States |
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| Authors: | Mitchell W. Pesesky Tahir Hussain Meghan Wallace Bin Wang Saadia Andleeb Carey-Ann D. Burnham Gautam Dantas |
| Affiliation: | Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA (M.W. Pesesky, T. Hussain. M. Wallace, B. Wang, C.D. Burnham, G. Dantas); ;National University of Sciences and Technology, Islamabad, Pakistan (T. Hussain, S. Andleeb) |
| Abstract: | To characterize the genomic context of New Delhi metallo-β-lactamase-1 (NDM-1) and Klebsiella pneumoniae carbapenemase (KPC), we sequenced 78 Enterobacteriaceae isolates from Pakistan and the United States encoding KPC, NDM-1, or no carbapenemase. High similarities of the results indicate rapid spread of carbapenem resistance between strains, including globally disseminated pathogens. |
| Keywords: | Carbapenems antimicrobial resistance Enterobacter Enterobacteriaceae Escherichia coli gene transfer genomics Klebsiella infections Klebsiella pneumonia bacteria multilocus sequence typing phylogeny plasmids transposases United States Pakistan antibiotic drugs beta-Lactam resistance beta-Lactamases beta-Lactams next-generation sequencing |