孕中不同时期联合免疫对HBV母婴传播的阻断效果

目的：探讨不同时期注射乙肝疫苗联合乙肝免疫球蛋对乙型肝炎病毒母婴传播的阻断作用。方法以HBsAg阳性孕妇及其婴儿为研究对象，A组105例于孕20周、24周、28周注射乙肝免疫球蛋白200 IU。B组106例孕妇于28周、32周、36周同法注射。两组新生儿出生后半小时内进行乙肝疫苗10μg、乙肝免疫球蛋白200 IU肌肉注射。结果 A组和B组新生儿出生时脐带静脉血、12月、24月外周静脉血HBsAg阳性率、HBsAb阳性率比较经χ2检验均有显著性差异（P〈0.05）。结论对HBsAg阳性孕妇孕20周、24周、28周及新生儿联合使用乙肝疫苗、乙肝免疫球蛋白可以有效减低HBV感染率。

The blocking effect on mother-infant dissemination of HBV from combined immunization at different stage of pregnancy

Objective To explore the blocking effect on mother-infant dissemination of hepatitis B virus （HBV） from injection of hepatitis B vaccine and human hepatitis B immunoglobulin （HBIG） at different stage of pregnancy. Methods 105 pregnant women in team A were injected HBIG 200 IU in week 20, 24 and 28 of pregnancy. 106 pregnant women in team B did so in week 28, 32 and 36 of pregnancy. And their new born babies were injected hepatitis B vaccine 10μg and HBIG 200 IU within half an hour after the babies were born. Results By comparing the HBsAg positive rates with the HBsAb positive rates of peripheral venous blood, the two rates were obviously different from each other during the three stages at which the new born infants were just born, 12 months old and 24 months old （P〈0.05）. Conclusion HBsAg positive pregnant women were injected hepatitis B vaccine in week 20, 24 and 28 of pregnancy. And their new born babies were injected hepatitis B vaccine and HBIG together. These decreased the rate of HBV infection effectively.