艾地苯醌治疗缺血性脑血管疾病的药理作用及临床应用

动物实验证实艾地苯醌具有对发生脑卒中的大鼠脑线粒体功能有激活作用、对脑能量代谢及脑功能障碍有改善作用,艾地苯醌的T_(1/2)为7.69h,T_(max)3.31h,C_(max)为290ng/mL,24h尿中排泄率为32％。艾地苯醌治疗脑动脉硬化症和脑梗死后遗症30例(男24例,女6例;年龄67±23a)总改善率90％,情感障碍、智力低下、行动异常等改善率73％-81％,不良反应轻微。

Pharmacology of idebenone in treating ischemic cerebrovascular disease and clinical application

The results of animal experiment demonstrated that idebenone activated brain mitochondria function in stroke rats, and improved brain energy metabolism and brain dysfunction. T was 7.69 h, Tmax was 3.31 h and Cmax was 290 ng/mL in blood. It was excreted 32% in 24 h urine. Thirty patients (M 24, F 6; age 67 + 23 a) with arteriosclerosis and sequelae of cerebral infarction were treated with idebenone, total response rate was 90%, improvement rating of emotional disturbances, hypophre-nia and behavior disorder were 73%-81%. Slight adverse effects (slight mental symptom in 2 patients) were encountered, but disappeared in decreasing dosage or withdrawal.