| 糖尿病对大鼠脑内葡萄糖转运蛋白表达的影响 |
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| 引用本文： | 李大伟,赵晓民,张玲,蔡洪信,夏青,杨明峰,夏作理. 糖尿病对大鼠脑内葡萄糖转运蛋白表达的影响[J]. 中华糖尿病杂志, 2008, 16(12): 755-756 |
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| 作者姓名： | 李大伟 赵晓民 张玲 蔡洪信 夏青 杨明峰 夏作理 |
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| 作者单位： | [1]271000 山东泰安,泰山医学院脑微循环重点实验室 [2]北京大学药学部,泰山医学院脑微循环重点实验室 |
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| 摘 要： | 目的探讨糖尿病（DM）对大鼠脑内葡萄糖转运蛋白1（GluT-1）和GluT-3表达的影响。方法应用免疫荧光检测DM大鼠脑内海马和皮质部位GluT-1和GluT-3表达情况。结果正常组大鼠海马部位GluT-1和GluT-3表达多于皮质部位。DM组大鼠脑内GluT-1表达减少（P＜0.01），GluT-3表达在海马部位有所增加（P＜0.01），皮质部位无明显变化（P＞0.05）。结论糖尿病引起脑内GluT-1和GluT-3表达水平变化，继而脑内葡萄糖转运发生相应变化以适应脑内能量代谢。
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| 关 键 词： | 糖尿病 大鼠 葡萄糖转运蛋白 |
Effect of diabetes on expression of glucose transporters in rat brain |
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| LI Da-wei,ZHAO Xiao-min,ZHANG Ling,et al.. Effect of diabetes on expression of glucose transporters in rat brain[J]. CHINESE JOURNAL OF DIABETES MELLITUS, 2008, 16(12): 755-756 |
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| Authors: | LI Da-wei ZHAO Xiao-min ZHANG Ling et al. |
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| Affiliation: | LI Da-wei,ZHAO Xiao-min,ZHANG Ling,et al.Institute of Cerebral Microcirculation.Taishan Medical University,Sh,ong Taian 271000,China. |
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| Abstract: | Objective To explore the effect of diabetes on expression of glucose transporter 1,and 3 (GluT 1 and 3). Methods After the successful establishment of diabetic rat model,immunofluorescence method was applied to detect the expressions of GluT-1 and 3 in cerebral hippocampus and cortex in rats. Results In normal rat brain,there were much more expressions of GluT-1 and 3 both in hippocampus and in cortex(P<0.01). However,the expression of GluT-1 decreased,and the expression of GluT-3 increased in hippocampus (... |
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| Keywords: | Diabetes Rat Glucose transport protein |
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