|
|||||
|
|
| 两种吡罗昔康凝胶体外经皮行为的比较 | |
| 引用本文： | 董平,孟现民,沙先谊,方晓玲.两种吡罗昔康凝胶体外经皮行为的比较[J].上海医药,2010,31(8):377-379. |
| 作者姓名： | 董平 孟现民 沙先谊 方晓玲 |
| 作者单位： | 1. 复旦大学药学院药剂学教研室,上海,200032;复旦大学附属公共卫生临床中心药剂科,上海,201508 2. 复旦大学附属公共卫生临床中心药剂科,上海,201508 3. 复旦大学药学院药剂学教研室,上海,200032 |
| 摘 要： | 目的：比较两种吡罗昔康凝胶的体外透皮吸收情况。方法：采用智能透皮试验仪对吡罗昔康凝胶进行体外经皮渗透实验,采用HPLC法测定透过离体大鼠皮肤的吡罗昔康含量。结果：样品A透皮速率达到（57.33±3.23）μg/（cm^2·h）,明显优于样品B（P〈0.01）。结论：不同厂家的吡罗昔康凝胶剂经皮性质差异显著。 |
| 关 键 词： | 凝胶剂 吡罗昔康 透皮吸收 |
The percutaneous absorption potential of two kinds of piroxicam gels:a comparative study in vitro |
|
| DONG Ping,MENG Xian-min,SHA Xian-yi,FANG Xiao-ling.The percutaneous absorption potential of two kinds of piroxicam gels:a comparative study in vitro[J].Shanghai Medical & Pharmaceutical Journal,2010,31(8):377-379. | |
| Authors: | DONG Ping MENG Xian-min SHA Xian-yi FANG Xiao-ling |
| Institution: | 1.Teaching and Research Group of Pharmaceutics,Institute of Pharmacy,Fudan University,Shanghai,200032 ;2.Department of Pharmacy,Public Health Clinical Center Affiliated to Fudan University,Shanghai,201508) |
| Abstract: | Objective：To compare the percutaneous absorption potential of two kinds of piroxicam gels in vitro.Methods：The transdermal potential of piroxicam gels were evaluated by the transdermal absorption test in vitro.The concentration of piroxicam which permeated the rats＇skin was measured by high-performance liquid chromatography（HPLC）.Results：The permeation rate of sample A was（57.33±3.23）μg /（cm^2·h）,which was superior than that of sample B（P〈0.01）.Conclusion：The transdermal potential of piroxicam gels from different manufacturers has significant differences. |
| Keywords: | gel piroxicam percutaneous absorption |
| 本文献已被 维普 万方数据 等数据库收录！ | |