淋巴管平滑肌瘤病3例临床病理观察

目的　观察淋巴管平滑肌瘤病 (LAM)的临床病理特点。方法　通过光镜、免疫组化方法对 3例LAM进行病理组织学观察。结果　 3例LAM根据发病部位不同 ,其临床表现也不同。镜下典型表现呈网状增生的淋巴管组织 ,管壁见增生的平滑肌细胞 ,排列成束状、梁状和乳头状 ,细胞呈梭形及上皮样形 ,分化良好。免疫组化示平滑肌细胞actin、desmin( ) ,上皮样平滑肌细胞HMB4 5、ER、PR可呈 ( )。结论　组织形态、免疫组化和病史相结合可以正确诊断该病。

Lymphangioleiomyomatosis: a clinicopathologic study of 3 case

Objective To study the clinicopathological charac t eristics of lymphangioleiomyomatosis (LAM). Methods Three case s of LAM were studied by histopathological observation and immunohistochemical st aining. Results The clinical manifestation of 3 cases LAM were differen t, depending on various sites. Histopathologically, the tumor was characterized by abnormal smooth muscle cells (LAM cells) proliferation around reticulate d lymphatics, and well-differentiated LAM cells varied from spindle-s haped cells to epithelioid cells. Immunohistochemical studied showes a strong re activity of most LAM cells for actin and desmin, and positivity for HMB-45 and est rogen and progesterone receptors was also observed mainly in epithelioid LAM cel ls. Conclusion LAM can be diagnosed by combination of histopatholog y with immunohistochemistry.