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| 中国湖北汉族人群HLA-DRB1基因多态性研究 | |
| 引用本文： | 孙孝云,侯炜,罗凡,丁晓华,杨光,锡谷达夫,石罔贤,杨占秋.中国湖北汉族人群HLA-DRB1基因多态性研究[J].武汉大学学报(医学版),2006,27(6):748-752. |
| 作者姓名： | 孙孝云 侯炜 罗凡 丁晓华 杨光 锡谷达夫 石罔贤 杨占秋 |
| 作者单位： | 1. 武汉大学期刊社,武汉,430072;武汉大学医学院病毒学国家重点实验室/病毒学研究所,武汉,430071 2. 武汉大学医学院病毒学国家重点实验室/病毒学研究所,武汉,430071 3. 日本福岛县立医科大学微生物系,日本福岛,960-1242 |
| 摘 要： | 目的:调查湖北汉族人群人类白细胞抗原(HLA)-DRB1基因多态性,获得完整准确的遗传学数据。方法:应用序列特异性引物聚合酶链反应(PCR-SSP)方法对213名随机选取无亲缘关系的湖北籍汉族健康体检者或健康献血员进行HLA-PDRB1基因型检测。结果:在213名正常个体中,发现基因频率(GF)较高的有DRB1*1501-1502(GF=11.0%)、*1101-1105(GF=8.5%)、*0901(GF=6.8%)、*1301-1302(GF=6.6%)、DRB4*0101(GF=19.0%)、DRB5*0101(GF=16.9%),低频率等位基因是DRB1*04、*1001和*0101-0103。结论:从基因水平分析了HLA-DRB1基因在湖北汉族群体中的分布特征,提供了一套比较完整准确的DRB1基因频率,为人类学和疾病相关性等研究提供了重要的参考数据。 |
| 关 键 词： | 遗传多态性 HLA-DRB1基因 基因频率 等位基因 |
| 文章编号： | 1671-8852(2006)06-0748-05 |
| 收稿时间： | 2006-08-31 |
| 修稿时间： | 2006年8月31日 |
An Investigation of the Polymorphism of HLA-DRBl Alleles in the Han Population in Hubei Province of China |
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| SUN Xiaoyun,HOU Wei,LUO Fan,DING Xiaohua,YANG Guang,TATSUO Suzutani,KEN Ishioka,YANG Zhangqiu.An Investigation of the Polymorphism of HLA-DRBl Alleles in the Han Population in Hubei Province of China[J].Medical Journal of Wuhan University,2006,27(6):748-752. | |
| Authors: | SUN Xiaoyun HOU Wei LUO Fan DING Xiaohua YANG Guang TATSUO Suzutani KEN Ishioka YANG Zhangqiu |
| Abstract: | Objective: To investigate at the DNA level the polymorphism of HLA-DRB1 gene in Han population in Hubei province of China.Methods: A total of 213 healthy examination persons or healthy donors without blood relationship in Han nationality of Hubei province were selected and analyzed by using the polymerase chain reaction/sequence specific primer(PCR/SSP) to test their HLA-DRB1 allele gene frequencies(GF).Results: The most frequent alleles were DRB1*1501-1502(GF=11.0%),*1101-1105(GF=8.5%),*0901(GF=6.8%),*1301-1302(GF=(6.6%),) DRB4*0101(GF=19.0%),DRB5*0101(GF=16.9%) and the lowest gene frequencies were DRB1*04,*1001 and *0101-0103.Their gene frequencies and allelic distributions were compared to those observed in other ethnic populations.Conclusion: The results showed the characteristic of HLA-PDRB1 distribution,and provided more comprehensive and accurate gene data that may serve as normal reference values for the population in Hubei province. |
| Keywords: | Polymorphism HLA-DRB1 Gene Gene Frequencies Allele |
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