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| 加替沙星pH敏感眼用原位凝胶体外释放的研究 | |
| 引用本文： | 徐亚静,胡容峰,尹辉,高宇. 加替沙星pH敏感眼用原位凝胶体外释放的研究[J]. 中国生化药物杂志, 2010, 31(2) |
| 作者姓名： | 徐亚静 胡容峰 尹辉 高宇 |
| 作者单位： | 安徽中医学院,药学院,安徽,合肥,230031;安徽省中药研究与开发重点实验室,安徽,合肥,230038 |
| 摘 要： | 目的研究加替沙星pH敏感眼用原位凝胶的体外释药特性与机制。方法采用改良桨法考察加替沙星pH敏感眼用原位凝胶的释药规律,并用无膜溶出法研究其释放机制。结果凝胶溶蚀和药物释放随着振荡频率和释放面积的增加而加快。其溶蚀度与释放度有明显相关性。结论体外的溶蚀行为与释放行为遵循零级动力学方程,凝胶溶蚀是决定药物释放的主要因素。 |
| 关 键 词： | 加替沙星 pH敏感 眼用原位凝胶 体外释药 |
Study on gatifloxacin in situ pH-sensitive gel release in vitro |
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| XU Ya-jing,HU Rong-feng,YIN Hui,GAO Yu. Study on gatifloxacin in situ pH-sensitive gel release in vitro[J]. Chinese Journal of Biochemical Pharmaceutics, 2010, 31(2) | |
| Authors: | XU Ya-jing HU Rong-feng YIN Hui GAO Yu |
| Affiliation: | XU Ya-jing1,2,HU Rong-feng1,YIN Hui1,GAO Yu1,2(1.School of Pharmacy,Anhui College of Traditional Chinese Medicine,Hefei 230031,China,2.Anhui Provincial Key Laboratory of R&D of Chinese Medicine,Hefei 230038,China) |
| Abstract: | Purpose To investigate the release properties of gatifloxacin in situ pH-sensitive gel in vitro.Methods The improved paddle method and the membraneless model were applied in assessing the drug release behavior.Results The gel erosion and drug release were increased with the increase of surface area and shaking frequency.The cumulative quantities of gel erosion were well correlated with the cumulative release of drug loaded in the gel.Conclusion Gatifloxacin was released from in situ pH-sensitive gel with ze... |
| Keywords: | gatifloxacin pH-sensitive in situ gel drug release in vitro |
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