| 枳椇子醋酸乙酯提取物对肝纤维化大鼠血清学指标及TGF-β1的影响 |
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| 引用本文： | 王飞,张洪,刘秀玲. 枳椇子醋酸乙酯提取物对肝纤维化大鼠血清学指标及TGF-β1的影响[J]. 中药材, 2006, 29(6): 577-580 |
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| 作者姓名： | 王飞 张洪 刘秀玲 |
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| 作者单位： | 1. 武汉大学人民医院药学部,湖北武汉430060;武汉大学药学院,湖北武汉430072
2. 武汉大学人民医院药学部,湖北武汉430060 |
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| 基金项目： | 湖北省科技攻关项目(No.2002AA301C61) |
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| 摘 要： |
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| 关 键 词： | 枳椇子 醋酸乙酯提取物 血清指标 转化生长因子 |
| 文章编号： | 1001-4454(2006)06-0577-04 |
| 收稿时间： | 2005-10-20 |
| 修稿时间： | 2005-10-20 |
Effect of the Ethyl Acetate Extract of Zhi Ju Zi on Serum Makers and the Expression of TGF-β1 in Rats with Hepatic Fibrosis |
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| WANG Fei,ZHANG Hong,LIU Xiu-ling. Effect of the Ethyl Acetate Extract of Zhi Ju Zi on Serum Makers and the Expression of TGF-β1 in Rats with Hepatic Fibrosis[J]. Journal of Chinese medicinal materials, 2006, 29(6): 577-580 |
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| Authors: | WANG Fei ZHANG Hong LIU Xiu-ling |
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| Affiliation: | 1. Renmin Hospital, Wuhan University, Wuhan 430060, China; 2. Department of pharmacy, Wuhan University, Wuhan 430072, China |
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| Abstract: | OBJECTIVE: To study the effect of the Ethyl Acetate Extract of Zhi Ju Zi on hepatic fibrosis. METHODS: Model of liver fibrosis in rats was induced by CCl4. The level of hyaluronic acid (HA) and laminin (LN) was detected by RIN. The expression of TGF-beta1 of the rat liver was detected by RT-PCR. Results: After treatment, the level of HA was apparently decreased (P < 0.05); the level of LN wsn't apparently different with the Colchicin group (P > 0.05); The expression of TGF-beta1, was apparently decreased (P < 0.05) CONCLUSION: The Ethyl Acetate Extract of Zhi Ju Zi can effectviely decrease the level of serum markers of hepatic fibrosis and the expression of TGF-beta1. |
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