| DKK-1与骨髓瘤骨病发生关系的研究进展 |
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| 引用本文： | 邵晓雁,欧阳建. DKK-1与骨髓瘤骨病发生关系的研究进展[J]. 中华肿瘤防治杂志, 2010, 17(4) |
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| 作者姓名： | 邵晓雁 欧阳建 |
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| 作者单位： | 南京中医药大学中西医结合鼓楼临床医学院血液科,江苏,南京,210008 |
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| 摘 要： | 目的:研究DKK-1(Dickkopf-1)在多发性骨髓瘤细胞中的表达水平,以及与骨髓瘤骨病发生的关系。方法:以DKK-1和骨髓瘤为检索词,检索1989-2009年中国知识资源总库CNKI系列数据库和PubMed数据库。纳入标准:1)DKK-1基因结构及生物学特征的研究;2)DKK-1与骨髓瘤发生关系研究。粗选有56篇关于DKK-1结构特点及其与骨髓瘤关系的研究文章,根据纳入标准,精选27篇文献。结果:DKK-1是Wnt/β-cate-nin信号通路的可溶性的抑制剂,目前已被认为在多发性骨髓瘤及骨髓瘤骨病的发生中起到一定作用。结论:中和DKK-1和(或)促进Wnt/β-catenin信号通路能够治疗骨病及抑制骨髓瘤细胞生长,提示DKK-1可能成为骨髓瘤骨病治疗的新靶点。
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| 关 键 词： | 多发性骨髓瘤 基因 DKK-1 综述文献 |
Progress in research of DKK-1 in myeloma bone disease |
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| SHAO Xiao-yan,OUYANG Jian. Progress in research of DKK-1 in myeloma bone disease[J]. Chinese Journal of Cancer Prevention and Treatment, 2010, 17(4) |
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| Authors: | SHAO Xiao-yan OUYANG Jian |
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| Affiliation: | SHAO+Xiao-yan,OUYANG+Jian+Department+of+Hematology,Gulou+Clinical+Medical+School+of+Combination+of+TCM+with+Western+Medicine+Nanjing+University+of+TCM,Nanjing+210008,P.R.China |
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| Abstract: | OBJECTIVE:To explore the level of DKK-1(Dickkopf-1)in multiple myeloma cells and its correlation with the occurrence of myeloma bone disease.METHODS:The articles were searched from CNKI and PubMed databases according to the key words,DKK-1 and myeloma,with the limit of literature from 1989 to 2009.Inclusion criteria:1)research of the structure and bionomics of DKK-1;2)the relationship between DKK-1 and myeloma.Totally 56 papers met the inclusion criteria,and finally 27 related papers were synthesized.RESULT... |
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| Keywords: | multiple myeloma genes DKK-1 review literature |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
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