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| 干扰素-ε诱导K562细胞凋亡的研究 | |
| 引用本文： | 杨光,周永安. 干扰素-ε诱导K562细胞凋亡的研究[J]. 山西职工医学院学报, 2008, 18(2): 1-3 |
| 作者姓名： | 杨光 周永安 |
| 作者单位： | 山西医科大学第二医院,山西,太原,030001 |
| 摘 要： | 目的：研究应用不同浓度的干扰素（IFN-ε）对K562细胞中野生型p53mRNA和Survivin mRNA表达影响及诱导凋亡作用。方法：应用RT—PCR法检测野生型p53 mRNA和Survivin mRNA的表达。结果：不同浓度的IFN-ε均可抑制Survivin基因的表达，并存在剂量与时间依赖性；可促进野生型p53mRNA的表达上调，但无剂量与时间依赖性。结论：IFN-ε可诱导K562细胞发生凋亡，促进野生型p53 mRNA表达上调和抑制Survivin mRNA的表达可能是其机制之一。 |
| 关 键 词： | 干扰素 K562细胞 凋亡 |
Study on K562 Cell Apoptosis Induced by interferon-ε |
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| YANG Guang,ZHOU Yongan. Study on K562 Cell Apoptosis Induced by interferon-ε[J]. Journal of Shanxi Medical College For Continuing Education, 2008, 18(2): 1-3 | |
| Authors: | YANG Guang ZHOU Yongan |
| Affiliation: | YANG Guang,ZHOU Yongan(The Second Hospital of Shanxi Medical University,Taiyuan 030001,Shanxi,China) |
| Abstract: | Objective： To study the expression and the induced apoptotic effect of different concentrations of interferon （IFN-ε） to wild-type p53 mRNA and Survivin mRNA of K562 cell. Methods： The expression of wild-type p53 mRNA and Survivin mRNA was detected by RT-PCR. Results： Different concentrations of IFN-ε could inhibit the expression of gene Survivin and occurred in a time-and-dose dependent manner. It could promote wild-type p53 mRNA expression increasing but no time-and-dose dependent manner occurred. Conclusion： It may be one of the mechanisms that IFN-ε may induce K562 cell apoptosis, promote the expression of wild-type p53 mRNA increasing and inhibit the expression of Survivin mRNA. |
| Keywords: | interferon K562 cell apoptosis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |