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| EpiSkin™和Epikutis®模型在体外皮肤刺激性和腐蚀性检测应用中的比较 | |
| 引用本文： | 张劲松,何立成,桑晶,康桦,匡荣,李杨. EpiSkin™和Epikutis®模型在体外皮肤刺激性和腐蚀性检测应用中的比较[J]. 中国现代应用药学, 2017, 34(4): 524-526 |
| 作者姓名： | 张劲松 何立成 桑晶 康桦 匡荣 李杨 |
| 作者单位： | 浙江省食品药品检验研究院, 杭州 310052,浙江省食品药品检验研究院, 杭州 310052,浙江省食品药品检验研究院, 杭州 310052,浙江省食品药品检验研究院, 杭州 310052,浙江省食品药品检验研究院, 杭州 310052,浙江省食品药品检验研究院, 杭州 310052 |
| 摘 要： | 目的 对Episkin™和Epikutis®模型在体外皮肤刺激性和腐蚀性检测各方面进行对比。方法 参考体外皮肤刺激实验（OECD指导原则439）和体外皮肤腐蚀实验（OECD指导原则431），对2种模型在质量控制、检测方法、结果判断、运输等方面进行探讨。结果 2种模型在质量控制、检测方法、结果判断等方面存在差异，在实验操作性和成本上也各有优缺点，但2种模型均能满足体外皮肤刺激性和腐蚀性实验要求。结论 2种模型均能很好地用于体外皮肤刺激性和腐蚀性检测。 |
| 关 键 词： | 皮肤刺激 皮肤腐蚀 Episkin™ 模型 Epikutis® 模型 |
| 收稿时间： | 2016-08-30 |
| 修稿时间： | 2016-12-29 |
Application Comparison of Episkin™ and Epikutis® Skin Model in Evaluating Skin Irritation and Skin Corrossion |
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| ZHANG Jinsong,HE Licheng,SANG Jing,KANG Hu,KUANG Rong and LI Yang. Application Comparison of Episkin™ and Epikutis® Skin Model in Evaluating Skin Irritation and Skin Corrossion[J]. The Chinese Journal of Modern Applied Pharmacy, 2017, 34(4): 524-526 | |
| Authors: | ZHANG Jinsong HE Licheng SANG Jing KANG Hu KUANG Rong LI Yang |
| Affiliation: | Zhejiang Institute for Food and Drug Control, Hangzhou 310052, china,Zhejiang Institute for Food and Drug Control, Hangzhou 310052, china,Zhejiang Institute for Food and Drug Control, Hangzhou 310052, china,Zhejiang Institute for Food and Drug Control, Hangzhou 310052, china,Zhejiang Institute for Food and Drug Control, Hangzhou 310052, china and Zhejiang Institute for Food and Drug Control, Hangzhou 310052, china |
| Abstract: | OBJECTIVE To compare two different skin model of Episkin™ and Epikutis® in evaluating skin irritation and skin corrosion. METHODS According to OECD Guide Line 439 and OECD Guide Line 431, two skin tissue models were compared considering of quality control, test method, interpretation of outcome and transportation respectively. RESULTS There were differences in quality control, test method, and result judgement between two models. Both two models could meet requirement for skin irritation and corrosion test, while each had their own merits in experimental operability and cost. CONCLUSION Epikutis™ and Epikutis™ are good skin tissue models for skin irritation and skin corrosion assays in vitro. |
| Keywords: | skin irritation skin corrosion Episkin™ model Epikutis® model |
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