| 山黄肝脂康颗粒抗肝纤维化作用的研究 |
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| 引用本文： | 贺彬,张裕民. 山黄肝脂康颗粒抗肝纤维化作用的研究[J]. 中医药导报, 2009, 15(3) |
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| 作者姓名： | 贺彬 张裕民 |
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| 作者单位： | 1. 益阳市人民医院,湖南,益阳,413001
2. 湖南中医药大学第一附属医院,湖南,长沙,410007 |
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| 摘 要： | 目的:探讨山黄肝脂康颗粒时CCl4致大鼠肝纤维化的作用及其机理.方法:将50只大鼠随机分为空白组,模型组,山黄肝脂康颗粒低剂量组和高剂量组,大黄<庶虫>虫丸组共5组,除空白组外,其余各组采用CCl4造肝纤维化模型,实验结束检测各组动物的肝功能和肝纤维化指标,观察肝组织病理学变化.结果:山黄肝脂康颗粒低剂量组和高剂量组以及大黄<庶虫>虫丸组均可使大鼠血清丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)的活性降低,白蛋白的含量升高;同时也可降低血清中透明质酸(HA)、Ⅲ型前胶原(PCⅢ)、ⅣC型胶原(ⅣC)及层粘连蛋白(LN)的含量.结论:山黄肝脂康颗粒具有较好的抗肝纤维化的作用.
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| 关 键 词： | 山黄肝脂康颗粒 肝纤维化 实验研究 |
Study of Shanhuang-ganzhikang Granule on the Rats of Liver Fibrosis |
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| HE Bin,ZHANG Yu-min. Study of Shanhuang-ganzhikang Granule on the Rats of Liver Fibrosis[J]. GUIDING JOURNAL OF TCM, 2009, 15(3) |
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| Authors: | HE Bin ZHANG Yu-min |
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| Affiliation: | HE Bin1,ZHANG Yu-min2 1.Pharmacy Department,People hospital of Yiyang,Hunan Province,Hunan Yiyang China 410007,2.First Affiliated Hospital,TCM University of Hunan,Changsha,Hunan China 410007 |
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| Abstract: | Objective:To investigate the effects of Shanhuang-ganzhikang Granule on the rat of liver fibrosis induced by CCl4.Methods: 50 rats were divided into five group(control group,model group,Shanhuang-ganzhikang Granule low and high dose group,Dahuangzecong Wan group) randomly.On the end,the indexes of liver function and liver fibrosis were examined,meanwhile,the liver tissue of pathology were observed.Results: ALT and AST were decreased in low and high dose group and the content of ALB were increased.At the sam... |
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| Keywords: | Shanhuang-ganzhikang Granule Liver Fibrosis Experimental Study |
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