准分子激光原位角膜磨镶术治疗高度近视术后干眼症临床研究

 目的了解高度近视患者行准分子激光原位角膜磨镶术(LASIK)术后干眼症状及相关指标的变化.方法84例(168只眼)高度近视患者行LASIK手术,分别观察术前、术后1周、1个月、2个月、3个月及6个月的干眼症状,包括干涩感、异物感等,并行角膜荧光素染色,记录泪液分泌量(Schirmer Ⅰ试验)和泪膜破裂时间(BUT),对数据进行统计学分析.结果术后1周至2个月干眼症状明显加重(P＜0.01),直至3个月角膜荧光素染色仍较术前明显增加(P＜0.05).术后1周至3个月泪液分泌量较术前明显减少(P＜0.01),术后1周至2个月BUT较术前明显缩短(P＜0.01).而术后1周有56眼(33.33%)达到干眼症诊断标准,术后1个月为61眼(40.39%),术后6个月恢复正常.结论高度近视LASIK术后发生干眼症为常见并发症,临床上应采取相应预防和治疗措施,以降低干眼症发生率,减少其危害.

Xerophthalmia after laser in situ keratomileusis in high myopic eyes

Objective To evaluate the symptoms and corresponding indexes of xerophthalmia eye after laser in situ keratomileusis(LASIK) in high myopic eyes.Methods One hundred and sixty-eight high myopic eyes were subjected to LASIK.The eyes were observed for subjective complaints of dry eye,fluorescein staining(Fl),Schirmer's test I,tear break-up time(BUT) preoperatively and 1 week,1,2,3,and 6 months postoperatively.Results The subjective complaints of dry eye were more severe after the operation. Fl staining dots were more concentrated within 3 months after operation.There were obvious decreases in BUT at 1 week,1 and 2 months postoperatively relative to the preoperative level(P<0.01).The Schirmer's test I result was lower at 1 week,1,2,and 3 months(P<0.01) after LASIK.Fifty-six eyes(33.33%) at 1 week and 61 eyes(40.39%) at 1 month were diagnosed as dry eye after LASIK and reached preoperative level at 6 months after.Conclusion Xeropnthalmia is common after LASIK in high myopic eyes. It is necessary to take preventive and therapeutic measures to reduce its incidence.