首页 | 本学科首页   官方微博 | 高级检索  
     

白细胞介素-10基因多态性与子宫内膜异位症的相关性
引用本文:李玉娟,谢静燕. 白细胞介素-10基因多态性与子宫内膜异位症的相关性[J]. 安徽医药, 2010, 14(7): 789-791. DOI: 10.3969/j.issn.1009-6469.2010.07.021
作者姓名:李玉娟  谢静燕
作者单位:南京医科大学附属南京第一医院妇产科,江苏,南京,210006;南京医科大学附属南京第一医院妇产科,江苏,南京,210006
基金项目:南京市科技局资助项目 
摘    要:
目的探讨白细胞介素-10(Interleukin-10,IL-10)基因多态性与子宫内膜异位症(Endometriosis EMs)发病的相关性。方法107例经手术治疗后,病理确认为EMs的患者,术中留取新鲜组织,对照组80例,取全血,提取DNA,采用聚合酶链式反应-限制性片段长度多态性(Polymerase chain reaction-restriction fragment length polymorphism PCR-RFLP)的方法,检测IL-10启动子区域-1082、-819、-592位点多态性。结果EMs组与对照组的IL-10启动子区域-1082、-819、-592基因型分布差异均无统计学意义(P〉0.05)。结论IL-10基因多态性与EMs的发病无明显相关性,未能够证实IL-10等位基因与EMs的遗传易感性有关。

关 键 词:白细胞介素-10  子宫内膜异位症  PCR-RFLP  基因多态性

Relativity of polymorphism of the interleukin-10 gene and endometriosis
LI Yu-juan,XIE Jing-yan. Relativity of polymorphism of the interleukin-10 gene and endometriosis[J]. Anhui Medical and Pharmaceutical Journal, 2010, 14(7): 789-791. DOI: 10.3969/j.issn.1009-6469.2010.07.021
Authors:LI Yu-juan  XIE Jing-yan
Affiliation:LI Yu-juan,XIE Jing-yan(The First Affiliated Hospital of Nanjing Medical Universty,Nanjing,Jiangsu 210006)
Abstract:
Aim To determine whether polymorphism of the interleukin-10(IL-10)gene is associated with endometriosis in a Chinese population.Method 107 women diagnosed with endometriosis by operation were taken as study group,and we sampled their fresh tissue during the operation.We extracted the DNA from the tissue,then used PCR-RFLP to examine the-1082,-819,-592 gene polymorphism in IL-10 gene.Results There was no statistically signigicant difference between the patients and the controls in the frequency of the IL-10-...
Keywords:PCR-RFLP
本文献已被 CNKI 维普 万方数据 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号