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Transhepatic bile acid kinetics in pigs and humans
Authors:Hannah M. Eggink  F. Samuel van Nierop  Marieke G. Schooneman  Anita Boelen  Andries Kalsbeek  Martijn Koehorst  Gabriella A.M. ten Have  L. Maurits de Brauw  Albert K. Groen  Johannes A. Romijn  Nicolaas E.P. Deutz  Maarten R. Soeters
Affiliation:1. Department of Endocrinology and Metabolism, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands;2. Hypothalamic Integration Mechanisms, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands;3. Department of Pediatrics, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands;4. Centre for Translational Research in Aging and Longevity, Dept. Health and Kinesiology, Texas A & M University, College Station, United States;5. Department of Surgery, MC Slotervaart, Amsterdam, The Netherlands;6. Department of Vascular Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands;g. Department of Internal Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
Abstract:
Keywords:Bile acids  TGR5  Porcine  Postprandial  Portal concentrations  BAs  bile acids  ASBT  apical sodium-dependent bile acid transporter  OST  organic solute transporter  NTCP  taurocholate cotransporting polypeptide  OATP  organic anion transporting polypeptide  mEH  microsomal epoxide hydroxylase  BSEP  bile salt export pump  FXR  farnesoid X receptor  TGR5  takeda G protein-coupled receptor 5  FGF  fibroblast growth factor  GLP-1  glucagon-like peptide 1  PAH  para-aminohippuric acid  TCA  trichloroacetic acid  A  abdominal aorta  V  caval vein  R  renal vein  P  portal vein  H  hepatic vein  HQ  hindquarter muscle  PDV  portal drained viscera  SPL  splanchnic compartment  K  kidneys  LC/MS/MS  liquid chromatography tandem mass spectrometry  UDCA  ursodeoxycholic acid  CA  cholic acid  CDCA  chenodeoxycholic acid  DCA  deoxycholic acid  LCA  lithocholic acid  HDCA  hyodeoxycholic acid  g  glycine-conjugated  t  taurine-conjugated  LOQ  lower limit of quantification  BMI  body mass index  ANOVA  analysis of variance  AUC  area under the curve  CYP7A1  cytochrome P450 7A1  KO  knock-out  SHP  short heterodimer partner  EC50  half maximal effective concentration
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