腭器官培养在腭裂发病机制研究中的应用

唇腭裂是人类最常见的出生缺陷之一,其发病机理复杂.多学科的研究表明,唇腭裂的病因涉及众多因素,受到多个因素的调控.其中导致腭裂发生的原因之一是腭板未能融合,而对于腭板融合过程的研究,在体内受诸多因素的限制,因此可以采用体外腭器官培养的方法进行研究.长期实践证明,与体内实验相比,体外腭器官培养模型可以模拟体内腭裂形成的过程.本文就腭器官培养方法在腭裂发病机制研究中的作用作一综述.

Appliance of palatal shelves organ culture method in the research of cleft palate pathogenesis

Cleft lip and palate is one of the most frequent congenital malformations in human.Multidisciplinary research shows that etiology of cleft lip and palate is related with many factors and regulated by complicated molecular mechanisms.One of the main etiologies of the cleft palate is that the failure of the fusion of the opposing secondary palates.The research for that step is limited by the complicated human factors in vivo.Therefore,we could adopt the method of palatal shelves organ culture in vitro.This article reviews appliance of palatal shelves organ culture methods in the research of cleft palate pathogenesis.