老年人晚期非小细胞肺癌三维立体适形放射治疗

目的 探讨老年人非小细胞肺癌(NSCLC)三维立体适形放射治疗(3D-CRT)的临床特点和疗效.方法 对108例由于内科禁忌证或其他情况不能手术的老年人晚期NSCLC施行3D-CRT,单次剂量5～8Gy,隔日1次,总剂量68～82Gy.结果 108例全部完成放射治疗计划,1、2、3年的平均生存率分别为65%、33%、28%.结论 对于有内科禁忌证或由于其他情况不能手术的老年人晚期NSCLC施行3D-CRT是一种比较有效的治疗手段,有助于提高生存率,改善生存质量,减少并发症的发生.

3-dimensional conformal radiotherapy(3D-CRT) for elderly patients with advanced stage of non-small cell lung cancer(NSCLC)

Objective To evaluate the clinical characteristics,efficacy and toxicity of three dimensional conformal radiotherapy(3D-CRT)for elderly patients suffering from advanced stage of non-small cell lung cancer(NSCLC).Methods From September 1999 to October 2006,with the use of Leibinger planning system,the authors performed 3-dimensional conformal radiotherapy(3D-CRT)for 108 elderly patients suffering from advanced stage of non-small cell lung cancer who had not received operation because of medical contraindications such as cardiac insufficiency,impaired pulmonary function,etc.For the patients with positive lymph metastasis,the primary tumor was treated with high dosages.Conventional radiotherapy was delivered,and the tumor site and draining lymphatic areas received 40~45Gy of radiation,followed by 3D-CRT.Results All patients received whole course of radiotherapy,and the total survival rate for 1,2,3 years was 65%,33% and 28%,respectively.Meanwhile,the radioreaction did not exceed grade 2 in all 108 cases.Conclusions 3-dimensional conformal radiotherapy was relatively an effective treatment for non-small cell lung cancer in elderly patients who could not withstand operations because of medical contraindications or other problems.The treatment was proved to improve total survival rate and life quality,relieve complications such as radiation pneumonia and radiation esophagitis.Therefore,3-dimensional conformal radiotherapy was recommended for elderly patients with advanced stage of lnon-small cell lung cancer.