| 益苷颗粒剂对大鼠利胆作用的研究 |
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| 引用本文： | 陈建萍,韩峰,韩超,李坤炜,杨斌.益苷颗粒剂对大鼠利胆作用的研究[J].中药新药与临床药理,2005,16(6):412-414. |
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| 作者姓名： | 陈建萍 韩峰 韩超 李坤炜 杨斌 |
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| 作者单位： | 1. 香港大学中医药学院
2. 中山大学医学院,广州,510089 |
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| 摘 要： | 目的观察不同剂量益苷颗粒对正常大鼠胆汁流量的影响.方法将正常大鼠随机分为空白对照组、阳性对照组、中药益苷颗粒剂大、中、小剂量组,做十二指肠插管给药,胆管插管收集胆汁;分段收集胆汁,比较给药前后流量的变化,分析药物对胆汁流量的影响,并测定用药前后胆汁中胆红素含量.结果中药益苷颗粒剂能使正常大鼠胆汁流量增加,且与剂量正相关.结论中药益苷颗粒剂具有利胆和促进胆红素排泄的作用.
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| 关 键 词： | 益苷颗粒剂 利胆 胆汁 胆红素 大鼠 |
| 文章编号： | 1003-9783（2005）06-0412-03 |
| 收稿时间： | 2005-09-08 |
| 修稿时间： | 2005年9月8日 |
Effect of Yigan Granules on Bile Secretion in Rats |
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| Chen Jianping,Han Feng,Han Chao,Li Kunwei,Yang Bin.Effect of Yigan Granules on Bile Secretion in Rats[J].Traditional Chinese Drug Research & Clinical Pharmacology,2005,16(6):412-414. |
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| Authors: | Chen Jianping Han Feng Han Chao Li Kunwei Yang Bin |
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| Institution: | 1.School of Chinese Medicine, the University of Hong Kong; 2. Sun Yat-Sen University of Medical Sciences, Guangzhou 510089 |
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| Abstract: | Objective To study the effect of Chinese Herb of Yigan Granules in different dosages on bile secretion in rats.Methods The rats were randomly divided into 5 groups: blank control group,positive control group and high,mod erate,low dosages of Yigan Granules groups.The medicines were administered thr ough duodenal intubation for the rats.Then the volume of bile were gathered by common bile duct intubations in different time,and the volume of bile and the contents of bilirubin in bile were tested before and after given drugs.Results Yigan Granules increased the bile secretion in a dose-dependent manner and promote the secretion of bilirubin.Conclusion Chinese Herb of Yigan granules has a choleretic effect. |
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| Keywords: | Yigan Granules Cholaneresis Bile Bilirubin Rats |
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