| 透明质酸钠的毒理学研究 |
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| 引用本文： | 郭风仙,高芃,耿桂英,汪会玲,刘海波,支媛. 透明质酸钠的毒理学研究[J]. 中国生化药物杂志, 2010, 31(5) |
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| 作者姓名： | 郭风仙 高芃 耿桂英 汪会玲 刘海波 支媛 |
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| 作者单位： | 1. 山东福瑞达生物医药有限公司,山东,济南,250101
2. 中国疾病预防控制中心营养与食品安全所,北京,100021 |
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| 摘 要： | 目的通过透明质酸钠(SH)的毒理学试验,探讨其食用安全性。方法按GB15193-2003食品安全性毒理学评价程序和方法的规定进行急性毒性试验、三项遗传毒性试验和90 d喂养试验。结果 SH属实际无毒,未见有致突变作用。SH喂养大鼠90 d,动物生长活动正常,未见对动物体重、食物利用率、血常规、血生化、脏器重量及脏体比、病理组织学检查结果有不良影响。结论 SH为无毒物质。
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| 关 键 词： | 透明质酸钠 毒性试验 大鼠 小鼠 |
Study on toxicology of sodium hyaluronate |
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| GUO Feng-xian,GAO Peng,GENG Gui-ying,WANG Hui-ling,LIU Hai-bo,ZHI Yuan. Study on toxicology of sodium hyaluronate[J]. Chinese Journal of Biochemical Pharmaceutics, 2010, 31(5) |
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| Authors: | GUO Feng-xian GAO Peng GENG Gui-ying WANG Hui-ling LIU Hai-bo ZHI Yuan |
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| Abstract: | Purpose To investigate the edible safety of sodium hyaluronate(SH)through the toxicology tests.Methods The tests were performed in accordance with the regulation of GB15193-2003 Procedures and Methods for Toxicological Assessment of Food,including acute toxicity test,three genotoxicity tests and 90 d feeding test.Results SH is practically non-toxic and has no mutagenic action.With SH mixed with a basic feed giving rats for 90 d,no behavioral changes were observed and no significant alterations were exhibited in body weight,food consumption,blood routine,clinical biochemistry,organ weight and organ/body ratios and histopathology.Conclusion SH is a non-toxic substance. |
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| Keywords: | sodium hyaluronate toxicity test rat mice |
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