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| 实时定量PCR检测Bcl-2/IgH融合基因在淋巴瘤中的应用 | |
| 引用本文： | 徐明,张学美. 实时定量PCR检测Bcl-2/IgH融合基因在淋巴瘤中的应用[J]. 医学综述, 2008, 14(6): 811-813 |
| 作者姓名： | 徐明 张学美 |
| 作者单位： | 昆明医学院第一附属医院血液科,昆明,650031 |
| 摘 要： | Bcl-2/IgH融合基因是淋巴瘤的肿瘤特异性标志,见于85%～90%的滤泡性淋巴瘤及30%的弥漫性大B细胞淋巴瘤患者。大量研究表明,该融合基因与滤泡性淋巴瘤和弥漫性大B细胞淋巴瘤有很好的相关性,对Bcl-2/IgH的定量检测能反应淋巴瘤的临床进程。现就实时定量PCR技术对Bcl-2/IgH融合基因的检测在淋巴瘤的分期、疗效评价、预测复发和预后评估等方面的临床意义进行综述。 |
| 关 键 词： | Bcl-2/IgH 融合基因 淋巴瘤 实时定量聚合酶链反应 |
| 文章编号： | 1006-2084(2008)06-0811-03 |
| 修稿时间： | 2007-03-28 |
Application of Real-time Quantitative PCR Detecting Bcl-2/IgH Fusion Gene in Lymphoma |
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| XU Ming,ZHANG Xue-mei. Application of Real-time Quantitative PCR Detecting Bcl-2/IgH Fusion Gene in Lymphoma[J]. Medical Recapitulate, 2008, 14(6): 811-813 | |
| Authors: | XU Ming ZHANG Xue-mei |
| Affiliation: | XU Ming,ZHANG Xue-mei.(Department of Hematology,First Affilliated Hospital of Kunming Medical College,Kunming 650031,China) |
| Abstract: | The Bcl-2/IgH fusion gene is the specific mark of malignant lymphoma.It was expressed in 85%~90% cases of follicular lymphoma(FL) and 30% diffuse large B-cell lymphoma(DLBCL).Studies showed that this fusion gene has good correlativity with follicular lymphoma and diffuse large B-cell lymphoma,and the quantitative detection of this fusion gene can reflect the clinical process of lymphoma.This article reviews clinical significance of Bcl-2/IgH fusion gene detection by RQ-PCR in the staging,evaluation of curat... |
| Keywords: | Bcl-2/IgH Fusion gene Lymphoma Real-Time Quantitative polymerase chain reaction |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |