Functional polymorphisms in cell death pathway genes FAS and FASL contribute to risk of lung cancer |
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| Authors: | Zhang X Miao X Sun T Tan W Qu S Xiong P Zhou Y Lin D |
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| Institution: | Department of Etiology and Carcinogenesis, Cancer Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. |
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| Abstract: | Background: The FAS and FASL system plays a key role in regulating apoptotic cell death and corruption of this signalling pathway has been shown to participate in immune escape and tumorigenesis. There is reduced expression of FAS but elevated expression of FASL in many types of human cancers including lung cancer. We recently reported an association between functional polymorphisms in FAS (–1377G→A) and FASL (–844T→C) and risk of oesophageal cancer. |
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