Identification and regional localization of a highly polymorphic dinucleotide repeat D11S614 to the interval in 11q23.3 flanked by recurrent translocation breakpoints |
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| Authors: | F. BENHAM R. SUGIYAMA D. HUNT G. GILLETT M. SMITH |
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| Affiliation: | The Galton Laboratory, Department of Genetics and Biometry and MRC Human Biochemical Genetics Units, University College London, Wolfson House, 4 Stephenson Way, London London NW1 2HE;Department of Paediatrics, University of California Irvine, Medical Science I, Irvine, California |
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| Abstract: | ![]()
A higly informative dinucleotide repeat polymorphism has been identified at the D11S614 locus on chromosome 11q23. Ten differen alleles have been observed at this locus, and the heterozygosity frequency is approximately 85%. Physical localization of this marker in a panel of somatic cell hybrids containing chromosome 11 translocation showed that is maps to 11q23.3, within the interval between the recurrent t(4;11) leukaemia breakpoint and the t(11;22) Ewing's sarcoma breakpoint. This physical mapping data is consistent withs the genetic mapping which indicates tight linkage to other markers in the q23.3 region including PBGD, CD3D and D11S29. Regional localization of highly informative markers such as D11S614 will facilitate integration of the genetic and physical maps. |
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