| 阿尔茨海默病和轻度认知障碍血CD4~＋T细胞计数变化 |
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| 引用本文： | 邱燕东,石胜良,毕桂南,黎彬如. 阿尔茨海默病和轻度认知障碍血CD4~＋T细胞计数变化[J]. 广西医学, 2010, 32(9): 1031-1033 |
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| 作者姓名： | 邱燕东 石胜良 毕桂南 黎彬如 |
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| 作者单位： | 1. 广西南宁市红十字会医院,南宁市,530021
2. 广西医科大学第一附属医院神经内科,南宁市,530021 |
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| 基金项目： | 广西科学基金，广西医疗卫生科学研究基金项目 |
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| 摘 要： | 目的观察阿尔茨海默病（AD）和轻度认知障碍（MCI）患者外周血CD4＋T细胞相对计数变化。方法采用流式细胞仪测定10例AD患者及14例MCI患者的CD4＋T细胞相对数,并与对照组11例比较。结果 AD组外周血CD4＋T细胞计数高于对照组（P〈0.01）和MCI组（P〈0.05）,MCI组与对照组相比差异无统计学意义（P〉0.05）。结论 CD4＋T细胞在AD炎症反应机制中起重要作用,但其对AD的影响作用还有待于进一步探讨。
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| 关 键 词： | 阿尔茨海默病 轻度认知障碍 CD4＋T细胞 |
The Changes of CD4+T Cells Count of Peripheral Blood in Patients with Mild Cognitive Impairment and Alzheimer's Disease |
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| Affiliation: | QIU Yan-dong,SHI Sheng-liang,BI Gui-nan(Department of Neurology,The First Affiliated Hospital,Guangxi Medical University,Nanning 530021,China) |
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| Abstract: | Objective To observe CD4＋T cells count of peripheral blood in patients with mild cognitive impairment（MCI）and Alzheimer＇s disease（AD）.Methods CD4＋T cells count of 10 patients with AD,14 patients with MCI and 11 controls were detected by flow cytometer（FCM）.Results CD4＋T cells count in peripheral blood of patientss with AD was higher than that of both the NC group（P0.01）and MCI group（P0.05）,no difference were found between the MCI group and the NC group（P0.05）.Conclusion CD4＋T cells may play an important role in the inflammatory reaction mechanism of AD,but the impact of CD4＋T cell on AD still needs to be further discussed. |
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| Keywords: | Alzheimer＇s disease Mild cognitive impairment CD4 positive thymocyte cell |
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