| 噻氯匹定对血小板血栓烷B_2生成的影响 |
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| 引用本文： | 王兆钺,何杨,万海英,李佩霞,阮长耿.噻氯匹定对血小板血栓烷B_2生成的影响[J].中国新药与临床杂志,1989(2). |
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| 作者姓名： | 王兆钺 何杨 万海英 李佩霞 阮长耿 |
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| 作者单位： | 苏州医学院血栓与止血研究室，苏州医学院血栓与止血研究室，苏州医学院血栓与止血研究室，苏州医学院血栓与止血研究室，苏州医学院血栓与止血研究室 苏州 215007，苏州 215007，苏州 215007，苏州 215007，苏州 215007 |
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| 摘 要： | 口服噻氯匹定(ticlopidine)能抑制胶原诱导的血小板血栓烷B_2(TXB_2)生成。大剂量(500mg/d)可使TXB_2生成很快降低,停药1wk后恢复正常。给小剂量(250mg/d)时TXB_2的减少出现较晚,恢复亦快。噻氯匹定对ADP诱导的血小板TXB_2生成也有显著抑制作用。噻氯匹定的抗血小板作用至少有部分与抑制花生四烯酸的代谢有关。
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| 关 键 词： | 噻氯匹定 血小板 血栓烷B_2 |
Effect of ticlopidine on thromboxane B_2 production by platelets |
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| WANG Zhao-Yue,HE Yang,WAN Hai-Ying,LI Pei-Xia,RUAN Chang-Geng.Effect of ticlopidine on thromboxane B_2 production by platelets[J].Chinese Journal of New Drugs and Clinical Remedies,1989(2). |
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| Authors: | WANG Zhao-Yue HE Yang WAN Hai-Ying LI Pei-Xia RUAN Chang-Geng |
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| Abstract: | Oral administration of ticlopidine had an inhibitory effect on collagen-induced platelet thromboxane B2(TXB2) production .In high dose group(500 mg/d), TXB2 production was rapidly decreased and returned to normal level 7 days after discontinuing ticlopidine; whereas in low dose group(250 mg/d),the decrease of TX B2 production appeared to be slower and recovered more rapidly when the drug was discontinued.It was also shown thai ticlopidine could significantly inhibit platelet TXB2 formation stimulated by adenosine diphosphate(ADP) .These results suggested that antiplatelet efficacy of ticlopidine was shown,in part,to inhibit arachidonic acid metabolism of platelets. |
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| Keywords: | ticlopidine platelet thromboxane B2 |
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