| 五氧化二钒对体外小鼠胚胎生长发育的影响 |
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| 引用本文： | 张天宝,孙棉龄.五氧化二钒对体外小鼠胚胎生长发育的影响[J].癌变．畸变．突变,1996,8(4):205-207. |
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| 作者姓名： | 张天宝 孙棉龄 |
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| 作者单位： | 第二军医大学卫生毒理学教研室(张天宝)，华西医科大学环境卫生学教研室(孙棉龄) |
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| 摘 要： | 本研究采用体外着床后全胚胎培养方法，观察了Ｖ２Ｏ５对小鼠胚胎生长发育的影响，结果显示，Ｖ２Ｏ５浓度达１５ｍｇ／ｌ时可影响胚胎的生长发育和形态分化，导致胚胎畸形率增加。在１５ｍｇ／ｌ以下浓度仅显示个别动物生长发育受影响，无明显的剂量－反应关系。
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| 关 键 词： | 五氧化二钒 全胚胎培养 小鼠 致畸性 |
EFFECT OF VANADIUM PENTOXIDE ON MOUSE EMBRYO CULTURED IN VITRO |
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| Abstract: | In this experiment,the effects of V 2O 5 on mouse embryo cultured in vitro were studied.Vanadium Pentoxide was added to 48h culture of 8.5 day whole mouse embryos.At concentration 15.0mg/l,embryonic growth retardation and dysmorphogenesis were observed,including reduced yolk sac diameter,head length,number of somite pairs,embryonic protein and DNA contents,and neural tube defects,deficite in axial rotation,brain development defects.At concentration 10.0mg/l and below,V 2O 5 had no apprent effects on embryonic growth and morphogenesis.This result consists with results in vivo.In comparison with effect of V 2O 5 on rat embryo cultured,indicated rat is more sensitive than mouse to developmental toxicity of vanadium. |
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| Keywords: | Vanadium Pentoxide Developmental toxicity Whole embryo culture Mouse |
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