| 胃癌肿瘤标志物及临床意义 |
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| 引用本文： | 李岩. 胃癌肿瘤标志物及临床意义[J]. 实用医院临床杂志, 2011, 8(1): 11-15 |
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| 作者姓名： | 李岩 |
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| 作者单位： | 中国医科大学附属盛京医院消化内科,辽宁,沈阳,110004 |
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| 摘 要： | 胃癌肿瘤标记物检测样本包括血清，腹水、胃液、组织等，其中血清标志物临床应用较为普遍，主要有CEA、CA72-4、CA50、CA19-9、CA242、MG—Ag及VEGF。胃液中包括传统肿瘤标记物CA724、CEA、CA19—9、CA242等及新近研究发现的α1-抗胰蛋白酶及MINT25甲基化的检测。腹水肿瘤标志物主要有ACEA、RegIV，其分别对判断胃癌预后及腹膜早期转移有一定的意义。胃癌组织肿瘤标志物p53基因、细胞周期相关抗原（Ki-67）、表皮生长因子受体（epidermal growth factor reeeptor，EGFR）、金属蛋白酶（metalloprofeinases，MMPs）及其抑制剂（tissue inhibitors of metalloproteinases，TIMPs）、环氧合酶-2（cyclooxygenase-2，COX-2）及CD133的检测对于判断预后有一定的价值。呆用多种标志物联合检测，或不同检测方法联合检测，有利于提高胃癌的早期诊断率。
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| 关 键 词： | 胃癌 腹水 组织 肿瘤标志物 血清 胃液 |
Tumor marker for gastric cancer and its clinical significance |
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| LI Yan. Tumor marker for gastric cancer and its clinical significance[J]. Practical Journal of Clinical Medicine, 2011, 8(1): 11-15 |
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| Authors: | LI Yan |
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| Affiliation: | LI Yan(Department of Gastroenterology,Shengjing Hospital of China Medical University,Shenyang 110004,China) |
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| Abstract: | The test samples of tumor markers for gastric cancer include blood serum,ascites,gastric juice,gastric tissues and so on.Serum tumor markers mainly include CEA,CA72-4,CA50,CA19-9,CA242,MG-Ag and VEGF.Traditional tumor markers in gastric juice include CA72-4,CEA,CA19-9,CA242 etc.Besides,the newly found alpha1-antitrypsin in recent studies and the methylation of MINT25 were tested.ACEA and RegIV are the tumor markers of ascites,which can predict the prognosis and early matastasis of peritoneum respectively.Tu... |
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| Keywords: | Gastric cancer Ascites Tissues Tumor markers Serum Gastric juice |
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