退白汤联合窄谱中波紫外线治疗白癜风的对照研究

目的:研究退白汤内服联合窄谱中波紫外线(NB-UVB)局部照射治疗白癜风的有效性和安全性.方法:将入选的137例白癜风患者分为3组.治疗组46例,内服退白汤,2次/d,予NB-UVB局部照射,初始剂量为0.5 J·cm-2,2次／周,每次剂量递增10％ ～20％,至出现红斑时维持治疗,疗程3月；对照Ⅰ组46例,仅内服退白汤；对照Ⅱ组45例,仅NB-UVB照射,疗程均为3月.结果:治疗组、对照Ⅰ组、对照Ⅱ组的有效率分别为73.91％,52.17％.48.89％,治疗组与对照Ⅰ组、对照Ⅱ组比较,差异均有统计学意义(P＜0.05),对照Ⅰ组和对照Ⅱ组比较差异无统计学意义；治疗组中头面部有效率显著优于躯干部和四肢,差异均有统计学意义(P＜0.01)；治疗组起效时间明显短于对照Ⅰ组、对照Ⅱ组,差异均有统计学意义(P＜0.01),对照Ⅰ组与对照Ⅱ组比较,差异无统计学意义.结论:退白汤联合NB-UVB治疗白癜风疗效显著,值得推广使用.

Efficiency of Tuibai Decoction Combined with NB-UVB Irradiation in Treating Vitiligo

Objective:To determine the clinical efficacy and safety of Tuibai decoction combined with NB-UVB irradiation in treating vitiligo.Method:One hundred and thirty-seven patients with vitiligo were divided into 3 groups.In treating group with 46 cases,Tuibai decoction was orally given twice a day,200 mL per time,and combined with NB-UVB irradiation twice a week with an initiated dose of 0.5 J·cm-2,and increasing the dose with 10%-20% per time till the erythema appeared with 3 month treating course.In control groupⅠwith 46 cases,only taken tuibai decoction.In control group Ⅱ with 45 cases,only NB-UVB irradiation was applied for 3 month treating course.Result: The efficiency in treatment group,the control groupⅠ,the control group Ⅱwas 73.91%,52.17%,48.89%,respectively.The difference between the treatment group and the two control groups was statistically significant(P<0.05),and the difference between the control group Ⅰand Ⅱ wa not statistically significant,efficiency of the head and face was remarkably higher than that of the trunk and extremities(P<0.01).The onset time of the treatment group was significantly shorter than that in control groups,and the difference was statistically significant(P<0.01),but the control group Ⅰcompared with control group,Ⅱ,the difference was not statistically significant.Conclusion:Tuibai decoction combined with NB-UVB irradiation is clinically effective and safe in treating vitligo.