莫沙必利和多潘立酮对卧床鼻饲的急性脑卒中患者肺部感染的影响

目的 观察莫沙必利和多潘立酮对卧床、鼻饲的急性脑卒中患者医院内肺部感染发生率的影响.方法 89例卧床、鼻饲的急性脑卒中患者,采用随机数字表法分为研究组(47例)和对照组(42例),两组均给予脑卒中常规治疗,研究组在此基础上服用莫沙必利5 mg,多潘立酮20 mg,每日3次,连续4周.观察住院4周内两组患者肺部感染发生率及鼻饲后3 h胃内容物残留例次及残留量,并进行统计学分析.结果 住院4周内,研究组肺部感染13例,对照组25例,发生率分别为27.66%(13/47)和59.52%(25/42),两组比较差异有统计学意义(P<0.01).鼻饲后3 h鼻胃管中可抽出食物的患者共26l例次,其中对照组237例次,残留量(112.17±32.54)ml;研究组24例次,残留量(50.80±15.38)ml,两组患者鼻饲后3 h有胃内容物残留的例次及残留量比较差异均有统计学意义(P<0.01).结论 对于卧床、鼻饲的急性脑卒中患者,在常规治疗基础上服用莫沙必利和多潘立酮,可显著降低患者医院内肺部感染发生率.

Effects of mosapride and domperidone on the pulmonary infection of acute stroke patients lying in bed and with nasal feeding

Objective To study the effects of mosapride and domperidone on the pulmonary infection of acute stroke patients lying in bed and with nasal feeding. Methods Eighty-nine acute stroke patients lying in bed and with nasal feeding were divided randomly into the treatment group (47 cases) and the control group (42 cases). The control group was treated routinely,and the treatment group was treated with mosapride 5 mg and domporidone 20 mg thrice a day for 4 weeks, besides routine therapy. The incidence rate of pulmonary infection, gastric residual volume (GRV) and the number of cases with gastric contents remaining after 3 hours of nasal feeding were studied. All data were analyzed statistically. Results In the treatment group, 13 cases had pulmonary infection,and the incidence rate was 27.66%(13/47). In the control group,25 cases had pulmonary infection,and the incidence rate was 59.52% (25/42). There was significant difference between the two groups (P < 0.01 ). Three hours after nasal feeding,24 cases with gastric contents remaining were discovered in the treatment group,and GRV was (50.80±15.38) ml. Two hundred and thirty-seven cases with gastric contents remaining were discovered in the control group, and GRV was (112.17±32.54) ml. Significance differences were also detected between the two groups (P<0.01). Conclusion As for the acute stroke patients lying in bed and with nasal feeding,mosapride and domperidone can remarkably cut down the pulmonary infection upon common treatment.