| 泄浊解毒方对溃疡性结肠炎大鼠T细胞亚群及白介素-10的影响 |
| |
| 引用本文： | 刘艳丛,刘建平,陈建权,朱叶珊,郎晓猛. 泄浊解毒方对溃疡性结肠炎大鼠T细胞亚群及白介素-10的影响[J]. 中华中医药杂志, 2011, 0(7): 1599-1601 |
| |
| 作者姓名： | 刘艳丛 刘建平 陈建权 朱叶珊 郎晓猛 |
| |
| 作者单位： | 唐山市丰润区人民医院;河北省中医院;河北医科大学; |
| |
| 基金项目： | 国家中医药管理局浊毒实验室资助项目(No.ZD200812-12); 河北省科技厅资助项目(No.09276102D-39)~~ |
| |
| 摘 要： | 目的:观察泄浊解毒方对溃疡性结肠炎大鼠T细胞亚群及白介素-10的影响并探讨其作用机制。方法:2,4,6-三硝基苯磺酸(TNBS)/乙醇溶液灌肠制备溃疡性结肠炎大鼠模型,实验设正常组、模型组、柳氮磺胺吡啶组、中药泄浊解毒方低、高剂量组;采用流式细胞术检测T细胞亚群(CD4+、CD8+),放射免疫法测定IL-10。结果:泄浊解毒方可明显升高CD+8含量,降低CD4+的水平,使CD4+/CD+8的比值保持一定比例,并能明显增加IL-10含量。结论:泄浊解毒方对大鼠溃疡性结肠炎有良好的治疗作用,其作用机制可能与调整T淋巴细胞亚群间的失衡,增加IL-10含量有关。
|
| 关 键 词： | 泄浊解毒方 溃疡性结肠炎 T细胞亚群 白介素-10 |
Effects of Xiezhuojiedu Decoction on expression of T cell subsets and IL-10 in ulcerative colitis rats |
| |
| LIU Yan-cong,LIU Jian-ping,CHEN Jian-quan,ZHU Ye-shan,LANG Xiao-meng. Effects of Xiezhuojiedu Decoction on expression of T cell subsets and IL-10 in ulcerative colitis rats[J]. China Journal of Traditional Chinese Medicine and Pharmacy, 2011, 0(7): 1599-1601 |
| |
| Authors: | LIU Yan-cong LIU Jian-ping CHEN Jian-quan ZHU Ye-shan LANG Xiao-meng |
| |
| Affiliation: | LIU Yan-cong1,LIU Jian-ping2,CHEN Jian-quan3,ZHU Ye-shan3,LANG Xiao-meng3(1Fengrun District Hospital of Tangshan,Tangshan 064000,China,2TCM Hospital of Hebei Province,Shijiazhuang 050011,3Hebei Medical University,Shijiazhuang 050017,China) |
| |
| Abstract: | Objective: To observe the effects of Xiezhuojiedu Decoction on expression of T cell subsets and IL-10 in ulcerative colitis rats,and explore its mechanism.Methods: 2,4,6 trinitrobenzene sulfonic acid(TNBS)/ethanol solution was administrated by enema to make ulcerative colitis rats models.Five groups were set up in the experiments: normal control group,modeling control group,salazosulfamide group,Xiezhuojiedu Decoction low-dose group and Xiezhuojiedu Decoction high-dose group;Determined cytokines T cell subs... |
| |
| Keywords: | Xiezhuojiedu Decoction Ulcerative colitis T lymphocyte subsets IL-10 |
| 本文献已被 CNKI 等数据库收录！ |
|
