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| 糖尿病神经病变发病机制的研究进展 | |
| 引用本文： | 薛莹,刘超. 糖尿病神经病变发病机制的研究进展[J]. 医学综述, 2007, 13(10): 761-763 |
| 作者姓名： | 薛莹 刘超 |
| 作者单位： | 南京医科大学第一附属医院内分泌科,南京,210029 |
| 摘 要： | 越来越多的证据表明,氧化应激是导致糖尿病并发症发生的最根本原因。糖尿病神经病变是糖尿病最常见的并发症之一,急性和慢性高血糖都会引起大量活性氧(ROS)的产生及天然抗氧化机制的破坏,进而激活多元醇途径、糖基化终末产物(AGE)途径、蛋白激酶C(PKC)途径和己糖胺途径,促进糖尿病神经病变的发展。 |
| 关 键 词： | 糖尿病神经病变 高血糖 氧化应激 |
| 文章编号： | 1006-2084（2007）10-0761-03 |
| 收稿时间： | 2006-09-10 |
| 修稿时间： | 2007-02-13 |
Study Progress of Pathogenisis of Diabetic Neuropathy |
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| XUE Ying,LIU Chao. Study Progress of Pathogenisis of Diabetic Neuropathy[J]. Medical Recapitulate, 2007, 13(10): 761-763 | |
| Authors: | XUE Ying LIU Chao |
| Affiliation: | Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanfing 210029, China |
| Abstract: | More and more evidences showed that that oxidative stress is the definite factor in the development of diabetic complications.Diabetic neuropathy is one of the most common chronic complications in diabetes.Both acute and chronic hyperglycemia can cause overproduction of reactive oxygen species(ROS) and destroy natural antioxidant system.Then the ROS activates the polyol pathway,increases intracellular AGE formation,activates PKC,and increases hexosamine pathway flux,which are all thereby promote the development of diabetic neuropathy. |
| Keywords: | Diabetic neuropathy Hyperglycemia Oxidative stress |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |