口腔黏膜肿瘤的光动力治疗

目的观察光动力疗法治疗口腔黏膜癌前病变及口腔癌的临床疗效。方法临床及病理确诊的口腔黏膜扁平苔藓和鳞癌患者各1例,静脉注射光敏剂PSD-007 5 mg/kg后6 h,应用波长630 nm的半导体激光以点状光纤照射,激光功率密度150 mW/cm2,每个光斑照射10～30 min,能量密度90～270 J/cm2。观察患者术中和术后的不良反应。术后4～5周进行近期临床疗效评价。结果 2例患者累计治疗18处病灶,其中15处病灶经1次治疗,2处病灶经2次治疗,1处病灶经3次治疗后痊愈,未见瘢痕形成。2例患者病灶愈合后均无口腔功能及感觉变化。结论光动力疗法具有靶向性好、选择性高、安全可靠、创伤小、可重复应用和对口腔功能无明显损害等优点,是一种安全、值得推广的治疗口腔黏膜癌前病变和口腔癌的高效疗法。

Photodynamic Therapy for Premalignant and Malignant Lesions of Oral Mucosa

Objective To observe the short-term effect of photodynamic therapy on premalignant and malignant lesions of oral mucosa.Methods One patient with histologically confirmed oral lichen planus and one patient with squamous cell carcinomas were included in the study.PSD-007 at 5mg/kg body weight was intravenously injected 6h before laser irradiation.A semiconductor laser emitting at 630nm was used as a light source.The power density of 150mW/cm2 was used,the exposure time was 10-30 minutes,and the total light dosage was 90-270J/cm2 at one light spot.Clinical and pathological examination was conducted 4-5 weeks after PDT to evaluate the short-term effect.ResultsEighteen foci in the two patients were treated.Of these foci,15 got complete remission（CR） after once treatment,two foci got partial remission（PR） after one treatment,and got CR after a repeat treatment,one focus got partial remission（PR） after the first treatment and became stable disease（SD） at second treatment,and got CR after the third treatment.No significantly adverse events occurred during and after PDT.ConclusionsPDT has the advantage of good selectivity,excellent tumor targeting and minimal damage to the function of oral cavity,suggesting that PDT is a safe,effective and minimally invasive procedure for premalignant and malignant lesions of oral mucosa.