中西药联合治疗非酒精性脂肪肝疗效观察

目的 探讨柴胡疏肝散联合多烯磷脂酰胆碱治疗非酒精性脂肪肝的临床效果.方法 90例患者随机分为三组,分别为多烯磷脂酰胆碱组（A组）、柴胡疏肝散组（B组）和柴胡疏肝散联合多烯磷脂酰胆碱组（C组）,每组30例.比较各组患者治疗前后临床症候评分、生化检查指标肝功能指标：丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）、谷氨酰转移酶（GGT）、总胆红素（TBIL）.血脂检查指标：总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HLD-C）、低密度脂蛋白胆固醇（LDL-C）]及B超检查下病情分度.结果 三组组内治疗前后临床症候评分、ALT、AST、GGT、TBIL、TC、TG、LDL-C差异均有统计学意义（均P＜0.05）.治疗后,C组临床症候评分、ALT、AST、TBIL、LDL-C的改善情况优于A、B组（P＜0.05）;对TC、TG 的作用,B、C组效果相当,均优于A组（均P＜0.05）.结论 柴胡疏肝散联合多烯磷脂酰胆碱治疗非酒精性脂肪肝的效果优于两药单独应用,有较好的临床应用前景.

Efficacy of combined treatment of traditional Chinese medicine and western medicine for non-alcoholic fatty liver disease

Objective To evaluate the efficacy of chaihu shugan san plus polyene phosphatidylcholine for non-alcoholic fatty liver disease(NAFLD).Methods Ninety patients with NAFLD were randomly divided into 3groups(each n=30):polyene phosphatidylcholine group(Group A),chaihu shugan san group(Group B),and chaihu shugan san plus polyene phosphatidylcholine group(Group C).The clinical symptom scores,biochemistry index (ALT,AST,GGT,TBIL,TC,TG,HLD-C,LDL-C),and B ultrasound examination were measured.Results There were significant differences in clinical symptom scores,ALT,AST,GGT,TBIL,TC,TG,and LDL-C between before and after treatment in the three groups(P＜0.05).After treatment,the clinical symptom scores,ALT,AST,TBIL,and LDL-C in Group C were significantly lower than those in Group A and Group B(P＜0.05).There were similar effects on TC and TG between Group B and Groop C,which were better than those in Group A(P＜0.05).Conclusion The efficacy of combined treatment of chaihu shugan san and polyene phosphatidylcholine was better than that of merely chaihu shugan san or tiopronin.