盐酸倍他司汀注射液联合丹参川芎嗪注射液治疗后循环缺血性眩晕的临床效果

目的 分析盐酸倍他司汀注射液联合丹参川芎嗪注射液治疗后循环缺血性眩晕的临床效果.方法 选取2019年10月至2020年12月我院收治的100例后循环缺血性眩晕患者为研究对象,根据随机数字表法将其分为对照组和研究组,各50例.两组患者均进行抗血小板聚集、减压、降脂等常规对症治疗.对照组采取盐酸倍他司汀注射液进行治疗,研究组联合盐酸倍他司汀注射液和丹参川芎嗪注射液进行治疗.比较两组的椎基底动脉平均血流速度、血液流变学指标、血脂水平、临床疗效及生活质量评分.结果 治疗后,两组的RVA、BA、LVA平均血流速度均较治疗前明显升高,且研究组高于对照组(P<0.05).治疗后,两组的血浆黏度、全血低切黏度、全血高切黏度、红细胞聚集指数、血浆纤维蛋白原水平均较治疗前明显降低,且研究组低于对照组(P<0.05).治疗后,两组的TC、TG、LDL-C水平均较治疗前明显降低,HDL-C水平均较治疗前明显升高,且研究组优于对照组(P<0.05).研究组的治疗总有效率明显高于对照组(P<0.05).治疗后,两组的GQOL-74各维度评分均较治疗前明显升高,且研究组高于对照组(P<0.05).结论 盐酸倍他司汀注射液联合丹参川芎嗪注射液治疗后循环缺血性眩晕的临床效果显著,能有效改善患者的椎基底动脉平均血流速度、血液流变学指标及血脂水平,提高其生活质量.

Clinical effect of betahistine hydrochloride injection combined with salvia miltiorrhiza ligustrazine injection in the treatment of posterior circulation ischemic vertigo

Objective To analyze the clinical effect of betahistine hydrochloride injection combined with salvia miltiorrhiza ligustrazine injection in the treatment of posterior circulation ischemic vertigo. Methods One hundred patients with posterior circulation ischemic vertigo treated in our hospital from October 2019 to December 2020 were selected as the research objects and divided into control group and study group according to random number table method, with 50 cases in each group. Both groups received routine symptomatic treatment such as antiplatelet aggregation, decompression and lipid-lowering. The control group was treated with betahistine hydrochloride injection,and the study group was treated with betahistine hydrochloride injection and salvia miltiorrhiza ligustrazine injection.The mean blood flow velocity of vertebrobasilar artery, hemorheological indexes, blood lipid levels, clinical efficacy and quality of life score were compared between the two groups. Results After treatment, the mean blood flow velocity of RVA, BA and LVA in the two groups were significantly higher than those before treatment, and those in the study group were higher than the control group(P <0.05). After treatment, the plasma viscosity, whole blood low shear viscosity, whole blood high shear viscosity, erythrocyte aggregation index and plasma fibrin level in the two groups were significantly lower than those before treatment, and those in the study group were lower than the control group(P <0.05). After treatment, the levels of TC, TG and LDL-C in the two groups were significantly lower than those before treatment, HDL-C level was significantly higher than that before treatment, and those in the study group were better than the control group(P<0.05). The total effective rate of treatment in the study group was significantly higher than that in the control group(P <0.05). After treatment, the GQOL-74 scores in the two groups were significantly higher than those before treatment, and those in the study group were higher than the control group( P <0.05).Conclusion Betahistine hydrochloride injection combined with salvia miltiorrhiza ligustrazine injection in the treatment of posterior circulation ischemic vertigo has a significant clinical effect, it can effectively improve the mean blood flow velocity of vertebrobasilar artery, hemorheological indexes and blood lipid level of patients, and improve their quality of life.