妇科止血灵片联合米非司酮治疗功能性子宫出血的Meta分析

目的 利用Meta分析方法对妇科止血灵片联合米非司酮治疗更年期功能性子宫出血的疗效和安全性进行评价分析。方法检索并选取1989—2020年国内、外公开发表的关于妇科止血灵片联合米非司酮治疗更年期功能性子宫出血的临床随机对照试验文献，筛选符合纳入标准的试验进行研究，采用Revman5.1软件统计并分析相关数据。结果 共有5项研究符合纳入标准。与对照组比较，妇科止血灵片联合米非司酮治疗更年期功能性子宫出血的神经功能缺损临床疗效比数比（OR）合并值为4.02(95%可信区间为2.09～7.73)。促黄体生成素水平的加权均数差（WMD）合并值为-1.90(95%可信区间为–2.35～-1.46)。卵泡刺激素水平的WMD合并值为-4.52(95%可信区间为-7.19～-1.85)。雌二醇水平的WMD合并值为–87.91(95%可信区间为-88.78～-87.03)。孕酮水平的WMD合并值为-3.97(95%可信区间为-5.71～-2.77)。用药安全风险OR合并值为0.89(95%可信区间为0.46～1.73)。结论 Meta分析结果显示，妇科止血灵片联合米非司酮治疗更年期功能性子宫出血安全、有...

Meta Analysis of Fuke Zhixue Ling Tablets Combined With Mifepristone in the Treatment of Climacteric Functional Uterine Bleeding

Objective To evaluate the efficacy and safety of Fuke Zhixue Ling tablets combined with mifepristone in the treatment of climacteric functional uterine bleeding by meta analysis.Methods The randomized controlled trials of Fuke Zhixue Ling tablets combined with mifepristone in the treatment of climacteric functional uterine bleeding published at home and abroad from 1989 to 2020 were searched and selected,and the trials that met the inclusion criteria were selected for research.The relevant data were analyzed by Revman 5.1 software.Results A total of 5 studies met the inclusion criteria.Compared with the control group,Fuke Zhixue Ling tablets tablets combined with mifepristone in the treatment of menopausal functional uterine bleeding with neurological deficit was 4.02(95%CI:2.09-7.73).The combined value of weighted mean difference(WMD)of luteinizing hormone was–1.90(95%confidence interval was–2.35-–1.46).The combined value of FSH WMD was–4.52(95%CI:–7.19-–1.85).The combined WMD of estradiol level was–87.91(95%CI:–88.78-–87.03).The combined value of progesterone WMD was–3.97(95%CI:–5.71-–2.77).The combined value of safety risk OR was 0.89(95%CI:0.46-1.73).Conclusion The results of Meta-analysis show that Fuke Zhixue Ling tablets combined with mifepristone is safe and effective in the treatment of menopausal functional uterine bleeding,which can reduce the levels of luteinizing hormone,follicle stimulating hormone,progesterone and estradiol,which is worthy of clinical application.