肾移植术后肺孢子菌肺炎感染与CD4细胞计数的相关性

目的 分析肺孢子菌肺炎感染与CD4细胞计数的相关性。方法 对武汉大学人民医院器官移植科2019年4月至2020年3月收治的134例肾移植术后1年内患者，其中54例患者确诊感染肺孢子菌肺炎，检测CD4细胞数量。分析肺孢子菌肺炎发病率与CD4细胞计数是否具有相关性，再根据CD4细胞计数分成3组，以t检验分别分析两组患者的住院天数、吸氧天数、肺部炎症吸收天数等相关指标，探究CD4细胞计数与肺孢子菌肺炎转归与预后之间的关系。结果 134例病例中有53例患者感染肺孢子菌肺炎，3组患病率分别0.237、0.720、0.813。根据分组分别用住院时间、吸氧时间、病灶吸收时间两两进行t检验，P值分别为0.667、0.517、0.779、0.335、0.863、0.150、0.404、0.139、0.405。结果显示均无统计学差异。结论 在肾移植患者术后，肺孢子菌肺炎的发病率随着CD4细胞计数的减少而上升，但CD4细胞计数与疾病预后没有明显关联。

Correlation between Pneumocystis pneumonia infection and cellular immune function after renal transplantation

Objective To analyze the correlation between pneumocystis pneumonia infection and cellular immune function.Methods From April 2019 to March 2020,134 patients with renal transplantation in our department were diagnosed with Pneumocystis pneumonia,54 of them were diagnosed as pneumocystis pneumonia.The number of CD4 cells was detected to reflect the cellular immune function of patients.The correlation between the incidence rate of pneumocystis pneumonia and cellular immune function was analyzed.Then the CD4 cell count was divided into three groups.The t-test was used to analyze the related indexes of the hospitalization days,the number of oxygen inhalation days,the number of days of pulmonary inflammatory absorption,and so on,and to explore the relationship between CD4 cell count and the prognosis of pneumocystis pneumonia and the prognosis of every two groups.Results Among 134 cases,53 patients were infected with pneumocystis pneumonia.The prevalence rates of the three groups were 0.237,0.720 and 0.813,respectively.According to the grouping,the time of hospitalization,the time of oxygen inhalation and the time of focus absorption were analyzed by t-test.The P values were 0.667,0.517,0.779,0.335,0.863,0.150,0.404,0.139 and 0.405 respectively.The results showed that there was no statistical difference.Conclusion The incidence rate of pneumocystis pneumonia in renal transplant recipients increased with the decrease of CD4 cell count,but CD4 cell count was not significantly associated with disease prognosis.