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Neurofibrillary pathology in the human paraventricular and supraoptic nuclei
Authors:Christian Schultz  Estifanos Ghebremedhin  Heiko Braak  Eva Braak
Affiliation:(1) Department of Morphology, Johann Wolfgang Goethe University, D-60590 Frankfurt/Main, Germany, DE;(2) Department of Anatomy, Johann Wolfgang Goethe University, Theodor-Stern-Kai 7, D-60590 Frankfurt/Main, Germany Tel.: 49-69-6301-6912; Fax: 49-69-6301-6425; e-mail: Schultz@em.uni-frankfurt.de, DE
Abstract:
Severe neurofibrillary changes were identified in the paraventricular and supraoptic nuclei of elderly individuals using markers for Alzheimer’s disease-related intraneuronal pathology. This neurofibrillary pathology is remarkable in that the magnocellular paraventricular and supraoptic nuclei are particularly resistant to Alzheimer’s disease. Moreover, the changes were observed even in non-demented controls, indicating that they develop independently of Alzheimer’s disease. The alterations in the paraventricular and supraoptic nuclei were consistently accompanied by neurofibrillary changes in the mediobasal hypothalamus. Received: 29 October 1996 / Revised, accepted: 24 January 1997
Keywords:Sex difference  Hypothalamus  Paraventricular nucleus  Supraoptic nucleus  Neurofibrillary changes
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