Suppression of colitis-related mouse colon carcinogenesis by a COX-2 inhibitor and PPAR ligands |
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| Authors: | Hiroyuki?Kohno mailto:h-kohno@kanazawa-med.ac.jp" title=" h-kohno@kanazawa-med.ac.jp" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author,Rikako?Suzuki,Shigeyuki?Sugie,Takuji?Tanaka |
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| Affiliation: | (1) Department of Oncologic Pathology, Kanazawa Medical University, 1-1 Daigaku, 920-0293 Uchinada, Ishikawa, Japan |
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| Abstract: | ![]()
Background It is generally assumed that inflammatory bowel disease (IBD)-related carcinogenesis occurs as a result of chronic inflammation. We previously developed a novel colitis-related mouse colon carcinogenesis model initiated with azoxymethane (AOM) and followed by dextran sodium sulfate (DSS). In the present study we investigated whether a cyclooxygenase (COX)-2 inhibitor nimesulide and ligands for peroxisome proliferator-activated receptors (PPARs), troglitazone (a PPARγ ligand) and bezafibrate (a PPARα ligand) inhibit colitis-related colon carcinogenesis using our model to evaluate the efficacy of these drugs in prevention of IBD-related colon carcinogenesis. |
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