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Elevation of serum corticosterone in rats by bremazocine, a kappa-opioid agonist |
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| Authors: | R W Fuller J D Leander |
| Affiliation: | 1. Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, U.S.A. Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, U.S.A.;2. Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, U.S.A. |
| Abstract: | Bremazocine at doses of 0.01 mg kg-1 s.c., and higher, increased serum corticosterone concentration several-fold in rats. The increase occurred within 20 min, was maximum at 40-60 min and subsided after 120 min. Pretreatment with naloxone (1-10 mg kg-1 s.c.) antagonized the corticosterone increase. These data support the view that kappa-opioid agonist activity of bremazocine mediated the corticosterone increase. |
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